HSP31 glutathione-independent methylglyoxalase [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: HSP31
Official Full Name: glutathione-independent methylglyoxalase
Primary source: SGD:S000002941
Locus tag: YDR533C
See related: AllianceGenome:SGD:S000002941; FungiDB:YDR533C; VEuPathDB:YDR533C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glyoxalase III activity and protein folding chaperone. Involved in several processes, including cellular response to oxidative stress; chaperone-mediated protein folding; and methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in P-body and cytoplasmic stress granule. Used to study Parkinson's disease; cancer; and early-onset Parkinson's disease. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See HSP31 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1501447..1502160, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsp31 has several biochemical activities including chaperone and detoxifying enzyme activities that modulate at various points of a stress pathway such as toxicity associated with protein misfolding.
Title: Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity.
delineation of Hsp31's role in the chaperone cycle has implications for understanding the role of the DJ-1 superfamily in controlling misfolded proteins in neurodegenerative disease and cancer
Title: The small heat shock protein Hsp31 cooperates with Hsp104 to modulate Sup35 prion aggregation.
The Saccharomyces cerevisiae HSP31 orthologue of Parkinson's disease-associated DJ-1 is a multi-stress response protein protecting cells against toxic glycolytic products.
Title: The budding yeast orthologue of Parkinson's disease-associated DJ-1 is a multi-stress response protein protecting cells against toxic glycolytic products.
Hsp31 chaperone family controls the steady state level of misfolded substrate.
Title: Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase.
Hsp31 maintains cellular glutathione and NADPH levels, thus conferring protection against oxidative stress
Title: Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae.
the protective role of Hsp31 against cellular stress
Title: Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process.
We find that the Hsp31 genes are strongly induced in diauxic shift and in stationary phase.
Title: Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glyoxalase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyoxalase III activity	IDA Inferred from Direct Assay more info	PubMed
enables glyoxalase III activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nutrient levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in lactate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: glutathione-independent methylglyoxalase

NP_010822.1

EC 4.2.1.130

Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1501447..1502160 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180841.1 → NP_010822.1 TPA: glutathione-independent methylglyoxalase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010822.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTF4, E9P8V9, Q04432

UniProtKB/TrEMBL

A6ZZC0, B3LFD8, B5VH52, C8Z693, G2WBR0, N1P7K8

Conserved Domains (1) summary

cd03147
Location:5 → 235

GATase1_Ydr533c_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in Saccharomyces cerevisiae Ydr533c protein