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RBA50 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852139, updated on 11-Sep-2024

Summary

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Official Symbol
RBA50
Primary source
SGD:S000002935
Locus tag
YDR527W
See related
AllianceGenome:SGD:S000002935; FungiDB:YDR527W; VEuPathDB:YDR527W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in transcription by RNA polymerase II. Located in cytoplasm. Orthologous to human RPAP1 (RNA polymerase II associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1491094..1492413)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Api2p Neighboring gene Sna2p Neighboring gene ncRNA Neighboring gene Hlr1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics. Jaime MD, et al. BMC Genomics, 2012 Jun 22. PMID 22727066, Free PMC Article
  2. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
  3. RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Jeronimo C, et al. Mol Cell Biol, 2004 Aug. PMID 15282305, Free PMC Article
  4. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
  5. Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Alonso B, et al. Cell Cycle, 2013 Feb 1. PMID 23324351, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rba50p
NP_010816.4
  • Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1491094..1492413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180835.4 → NP_010816.4  TPA: Rba50p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010816.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTE8, Q04418
    UniProtKB/TrEMBL
    A6ZZB4, B3LFE3, B5VH46, C8Z687, G2WBQ4, N1P945
    Conserved Domains (3) summary
    TIGR01612
    Location:62 → 289
    235kDa-fam; reticulocyte binding/rhoptry protein
    pfam08620
    Location:289 → 357
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:80 → 124
    RPAP1_N; RPAP1-like, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04418.2

Gene LinkOut

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