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GRH1 Grh1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852129, updated on 2-Nov-2024

Summary

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Official Symbol
GRH1
Official Full Name
Grh1p
Primary source
SGD:S000002925
Locus tag
YDR517W
See related
AllianceGenome:SGD:S000002925; FungiDB:YDR517W; VEuPathDB:YDR517W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular response to starvation; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein secretion. Located in Golgi membrane and cis-Golgi network. Orthologous to several human genes including GORASP2 (golgi reassembly stacking protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GRH1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1477239..1478357)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Slf1p Neighboring gene putative glucokinase Neighboring gene protein disulfide isomerase EUG1 Neighboring gene peptidylprolyl isomerase family protein FPR2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast GRASP Grh1 displays a high polypeptide backbone mobility along with an amyloidogenic behavior. Fontana NA, et al. Sci Rep, 2018 Oct 24. PMID 30356074, Free PMC Article
  2. The yeast GRASP Grh1 colocalizes with COPII and is dispensable for organizing the secretory pathway. Levi SK, et al. Traffic, 2010 Sep. PMID 20573068, Free PMC Article
  3. Genetic selection of peptide inhibitors of biological pathways. Norman TC, et al. Science, 1999 Jul 23. PMID 10417390
  4. Golgi membrane-associated degradation pathway in yeast and mammals. Yamaguchi H, et al. EMBO J, 2016 Sep 15. PMID 27511903, Free PMC Article
  5. Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. Bruns C, et al. J Cell Biol, 2011 Dec 12. PMID 22144692, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Grh1-Bug1 complex contributes to a redundant network of interactions that mediates consumption of COPII vesicles and formation of the cis-Golgi
    Title: The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Grh1p
NP_010805.1
  • Acetylated cis-Golgi protein, homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; required for unconventional protein secretion (UPS) of Acb1p in response to starvation; forms amyloid fibrils under heat shock; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1477239..1478357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180825.1 → NP_010805.1  TPA: Grh1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010805.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTD8, Q04410
    UniProtKB/TrEMBL
    B3LFF3, C7GKV0, C8Z673, N1P7Q5
    Conserved Domains (1) summary
    COG5233
    Location:1 → 372
    GRH1; Peripheral Golgi membrane protein [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04410.1

Gene LinkOut

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