VPS3 CORVET complex subunit VPS3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: VPS3
Gene description: CORVET complex subunit VPS3
Primary source: FungiDB:YDR495C
Locus tag: YDR495C
See related: SGD:S000002903; AllianceGenome:SGD:S000002903; VEuPathDB:YDR495C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PEP6; VPL3; VPT17
Summary: Involved in protein targeting to vacuole; vacuolar acidification; and vacuole inheritance. Located in endosome. Part of CORVET complex. Orthologous to human TGFBRAP1 (transforming growth factor beta receptor associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole.
Title: Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole.
C-terminal alpha-helical segments of VPS3 and VPS8 are necessary for CORVET assembly and function.
Title: The N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.
Vps3 has an epistatic relationship with Pdr5, a major yeast multidrug transporter.
Title: Pdr5-mediated multidrug resistance requires the CPY-vacuolar sorting protein Vps3: are xenobiotic compounds routed from the vacuole to plasma membrane transporters for efflux?

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar acidification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CORVET complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_010783.3

Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase

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The following sections contain reference sequences that belong to a specific genome build. Explain