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VPS52 Vps52p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852095, updated on 2-Nov-2024

Summary

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Official Symbol
VPS52
Official Full Name
Vps52p
Primary source
SGD:S000002892
Locus tag
YDR484W
See related
AllianceGenome:SGD:S000002892; FungiDB:YDR484W; VEuPathDB:YDR484W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAC2
Summary
Predicted to enable syntaxin binding activity. Involved in several processes, including Golgi to vacuole transport; intracellular sphingolipid homeostasis; and retrograde transport, endosome to Golgi. Located in Golgi apparatus. Part of GARP complex. Orthologous to human VPS52 (VPS52 subunit of GARP complex). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VPS52 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1422763..1424688)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene U2-type spliceosomal complex subunit CWC21 Neighboring gene alpha-1,2-mannosyltransferase KRE2 Neighboring gene Vps72p Neighboring gene Vps60p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of the SAC2 gene of Saccharomyces cerevisiae. Kölling R, et al. Yeast, 1994 Sep. PMID 7754710
  2. Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae. Markovich S, et al. Antimicrob Agents Chemother, 2004 Oct. PMID 15388447, Free PMC Article
  3. Suppressors of yeast actin mutations. Novick P, et al. Genetics, 1989 Apr. PMID 2656401, Free PMC Article
  4. Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition. Quenneville NR, et al. Mol Biol Cell, 2006 Apr. PMID 16452629, Free PMC Article
  5. Atg9 sorting from mitochondria is impaired in early secretion and VFT-complex mutants in Saccharomyces cerevisiae. Reggiori F, et al. J Cell Sci, 2006 Jul 15. PMID 16787937, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sphingolipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of GARP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GARP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vps52p
NP_010772.1
  • Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1422763..1424688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180792.1 → NP_010772.1  TPA: Vps52p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTA7, P39904, Q03379
    UniProtKB/TrEMBL
    A6ZZ73, B3LFI2, B5VH11, C8Z642, G2WBL3, N1P7E3
    Conserved Domains (1) summary
    cl19950
    Location:47 → 607
    Sec3_C; Exocyst complex component Sec3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39904.2

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