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SDC1 Sdc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852080, updated on 18-Sep-2024

Summary

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Official Symbol
SDC1
Official Full Name
Sdc1p
Primary source
SGD:S000002877
Locus tag
YDR469W
See related
AllianceGenome:SGD:S000002877; FungiDB:YDR469W; VEuPathDB:YDR469W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPS25; SAF19
Summary
Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation and subtelomeric heterochromatin assembly. Part of Set1C/COMPASS complex. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SDC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1399015..1399542)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein kinase PKH3 Neighboring gene Tlg1p Neighboring gene Ugo1p Neighboring gene ribosomal 60S subunit protein L27B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. South PF, et al. J Biol Chem, 2010 Jan 1. PMID 19897479, Free PMC Article
  2. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Sun ZW, et al. Nature, 2002 Jul 4. PMID 12077605
  3. Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Hsu PL, et al. Cell, 2018 Aug 23. PMID 30100181, Free PMC Article
  4. Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination. Huang F, et al. J Biol Chem, 2015 Nov 27. PMID 26451043, Free PMC Article
  5. Molecular basis for DPY-30 association to COMPASS-like and NURF complexes. Tremblay V, et al. Structure, 2014 Dec 2. PMID 25456412, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bre2 and Sdc1 are shown to directly interact, and it is shown that the association of this heteromeric complex is needed for proper H3K4 methylation and gene expression to occur.
    Title: A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sdc1p
NP_010757.3
  • Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1399015..1399542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180777.3 → NP_010757.3  TPA: Sdc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010757.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT93, Q03323
    UniProtKB/TrEMBL
    A6ZZ59, B3LFJ6, B5VGZ8, C7GKR0, C8Z628, G2WBJ9, N1P8Z7
    Conserved Domains (1) summary
    pfam05186
    Location:122 → 162
    Dpy-30; Dpy-30 motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03323.1

Gene LinkOut

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