TLG1 Tlg1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TLG1
Official Full Name: Tlg1p
Primary source: SGD:S000002876
Locus tag: YDR468C
See related: AllianceGenome:SGD:S000002876; FungiDB:YDR468C; VEuPathDB:YDR468C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables SNAP receptor activity. Involved in endocytosis and vesicle fusion. Located in endosome and trans-Golgi network. Part of SNARE complex. Orthologous to human STX10 (syntaxin 10) and STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TLG1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1398026..1398700, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

determined the structure of the N-terminal domain of Tlg1 bound to a peptide from the N terminus of Vps51
Title: Structural analysis of the interaction between the SNARE Tlg1 and Vps51.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tlg1p

NP_010756.3

Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1398026..1398700 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180776.3 → NP_010756.3 TPA: Tlg1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010756.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT92, Q03322

UniProtKB/TrEMBL

A6ZZ58, B3LFJ7, B5VGZ7, C7GKQ9, C8Z627, G2WBJ8, N1P7K3

Conserved Domains (2) summary

cd15851
Location:135 → 200

SNARE_Syntaxin6; SNARE motif of syntaxin 6

cd21444
Location:6 → 92

SNARE_NTD_Tlg1p-like; N-terminal domain of t-SNARE affecting a late Golgi compartment protein 1 and similar proteins