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PFA5 palmitoyltransferase PFA5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852070, updated on 18-Sep-2024

Summary

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Official Symbol
PFA5
Official Full Name
palmitoyltransferase PFA5
Primary source
SGD:S000002867
Locus tag
YDR459C
See related
AllianceGenome:SGD:S000002867; FungiDB:YDR459C; VEuPathDB:YDR459C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables palmitoyltransferase activity. Involved in protein palmitoylation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PFA5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1382319..1383443, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TOM1 Neighboring gene Heh2p Neighboring gene TFIIH/NER complex subunit TFB3 Neighboring gene mating pheromone a

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys JE, et al. J Cell Biol, 2005 Sep 26. PMID 16186255, Free PMC Article
  2. Purification and characterization of recombinant protein acyltransferases. Budde C, et al. Methods, 2006 Oct. PMID 17012026, Free PMC Article
  3. Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Bartels DJ, et al. Mol Cell Biol, 1999 Oct. PMID 10490616, Free PMC Article
  4. Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3. Nadolski MJ, et al. J Biol Chem, 2009 Jun 26. PMID 19416974, Free PMC Article
  5. Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism. Hou H, et al. Traffic, 2009 Aug. PMID 19453970

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell periphery HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
palmitoyltransferase PFA5
NP_010747.1
  • Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1382319..1383443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180767.1 → NP_010747.1  TPA: palmitoyltransferase PFA5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010747.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT83, Q03289
    UniProtKB/TrEMBL
    A6ZZ49, B3LFK6, B5VGZ1, C7GKQ0, C8Z617, G2WBI9, N1P7J4
    Conserved Domains (1) summary
    COG5273
    Location:9 → 335
    COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03289.1

Gene LinkOut

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