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RPS18A ribosomal 40S subunit protein S18A [ Saccharomyces cerevisiae S288C ]

Gene ID: 852061, updated on 3-Nov-2024

Summary

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Official Symbol
RPS18A
Official Full Name
ribosomal 40S subunit protein S18A
Primary source
SGD:S000002858
Locus tag
YDR450W
See related
AllianceGenome:SGD:S000002858; FungiDB:YDR450W; VEuPathDB:YDR450W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable rRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal subunit export from nucleus. Located in mitochondrion. Orthologous to human RPS18 (ribosomal protein S18). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPS18A in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (1359923..1360798)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chromatin-binding transcription regulator ADA2 Neighboring gene snoRNA-binding rRNA-processing protein UTP6 Neighboring gene Yhp1p Neighboring gene endopolyphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Chiocchetti A, et al. Exp Gerontol, 2007 Apr. PMID 17174052
  2. A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling. Kasari V, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31299085, Free PMC Article
  3. Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA. Tabb-Massey A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627813, Free PMC Article
  4. Functional specificity among ribosomal proteins regulates gene expression. Komili S, et al. Cell, 2007 Nov 2. PMID 17981122, Free PMC Article
  5. Genetic interactions of yeast NEP1 (EMG1), encoding an essential factor in ribosome biogenesis. Schilling V, et al. Yeast, 2012 May. PMID 22588997

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosomal 40S subunit protein S18A
NP_010738.1
  • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1359923..1360798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180758.1 → NP_010738.1  TPA: ribosomal 40S subunit protein S18A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010738.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT75, P0CX55, P0CX56, P35271
    UniProtKB/TrEMBL
    A6ZM36, B3LLM6, C7GKP2, C7GT56, C8Z608, G2WK26, N1NZE5
    Conserved Domains (1) summary
    PTZ00134
    Location:1 → 144
    PTZ00134; 40S ribosomal protein S18; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX55.1
P0CX56.1

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Research Materials
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