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SSN2 Ssn2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852053, updated on 14-Nov-2024

Summary

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Official Symbol
SSN2
Official Full Name
Ssn2p
Primary source
SGD:S000002851
Locus tag
YDR443C
See related
AllianceGenome:SGD:S000002851; FungiDB:YDR443C; VEuPathDB:YDR443C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MED13; NUT8; RYE3; SCA1; SRB9; SSX5; UME2
Summary
Enables cyclin binding activity and transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription from RNA polymerase II promoter by galactose. Part of mediator complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and dextro-looped transposition of the great arteries. Orthologous to human MED13 (mediator complex subunit 13) and MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SSN2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1345676..1349938, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene histone methyltransferase DOT1 Neighboring gene adenine phosphoribosyltransferase APT2 Neighboring gene putative hydrolase Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [CaSRB9, a novel Candida albicans gene, plays a role in morphogenesis of Saccharomyces cerevisiae]. Zhou Z, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 May. PMID 12019441
  2. The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose. Surosky RT, et al. Mol Cell Biol, 1994 May. PMID 8164691, Free PMC Article
  3. Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II. Yuryev A, et al. Genetics, 1996 Jun. PMID 8725217, Free PMC Article
  4. Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C. Khakhina S, et al. Mol Biol Cell, 2014 Sep 15. PMID 25057017, Free PMC Article
  5. Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation. Hanley SE, et al. Mol Biol Cell, 2024 Nov 1. PMID 39320938

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Releasing cyclin C from the nucleus involves both its phosphorylation by Slt2p coupled with Med13p destruction.
    Title: Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C.
  2. Data show that two components of the RNA polymerase II machinery, Med13 (Srb9) and Spt8, are two-hybrid partners of the conserved TFIIS N-terminal domain.
    Title: Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ssn2p
NP_010731.3
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1345676..1349938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180751.3 → NP_010731.3  TPA: Ssn2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010731.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT69, P38931
    UniProtKB/TrEMBL
    B3LFL7, N1P7I3
    Conserved Domains (2) summary
    pfam06333
    Location:1106 → 1385
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:8 → 279
    Med13_N; Mediator complex subunit 13 N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38931.2

Gene LinkOut

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