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LRS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852049, updated on 22-Aug-2024

Summary

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Official Symbol
LRS4
Primary source
FungiDB:YDR439W
Locus tag
YDR439W
See related
SGD:S000002847; AllianceGenome:SGD:S000002847; VEuPathDB:YDR439W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in monopolar spindle attachment to meiosis I kinetochore; nucleolus organization; and replication-born double-strand break repair via sister chromatid exchange. Located in nucleolus. Part of monopolin complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1339676..1340719)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19 Neighboring gene Thi74p Neighboring gene histone methyltransferase DOT1 Neighboring gene adenine phosphoribosyltransferase APT2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dyskerin, tRNA genes, and condensin tether pericentric chromatin to the spindle axis in mitosis. Snider CE, et al. J Cell Biol, 2014 Oct 27. PMID 25332162, Free PMC Article
  2. The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation. Brito IL, et al. Cell Cycle, 2010 Sep 1. PMID 20818155, Free PMC Article
  3. Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. Ye Q, et al. EMBO J, 2016 Oct 4. PMID 27491543, Free PMC Article
  4. Condensins promote coorientation of sister chromatids during meiosis I in budding yeast. Brito IL, et al. Genetics, 2010 May. PMID 20194961, Free PMC Article
  5. Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I. Lee BH, et al. Curr Biol, 2004 Dec 29. PMID 15620644

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Lrs4-Csm1 complex localize to kinetochores during anaphase and is important for ensuring accurate chromosome segregation. (LRS4 protein)
    Title: The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation.
  2. Csm1(Psc1)/Lrs4(Mde4) functions as a molecular clamp, crosslinking kinetochore components to enforce sister chromatid co-orientation in S. cerevisiae meiosis I and to suppress merotelic attachment in S. pombe mitosis.
    Title: The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.
  3. Dbf4-dependent Cdc7 kinase (DDK) regulates monopolin localization together with the polo-kinase Cdc5 bound to Spo13, probably through phosphorylation of the monopolin subunit Lrs4
    Title: Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to nucleolar rDNA repeats IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA chromatin condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle attachment to meiosis I kinetochore IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of monopolin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lrs4p
NP_010727.1
  • Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1339676..1340719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180747.1 → NP_010727.1  TPA: Lrs4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010727.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT66, Q04087
    UniProtKB/TrEMBL
    A6ZZ33, B3LFM0, C7GTP2, C8Z5Z9, G2WBH2, N1P793
    Conserved Domains (1) summary
    pfam10422
    Location:5 → 232
    LRS4; Monopolin complex subunit LRS4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04087.1

Gene LinkOut

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