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SIP1 Sip1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852032, updated on 2-Nov-2024

Summary

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Official Symbol
SIP1
Official Full Name
Sip1p
Primary source
SGD:S000002830
Locus tag
YDR422C
See related
AllianceGenome:SGD:S000002830; FungiDB:YDR422C; VEuPathDB:YDR422C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to AMP-activated protein kinase activity. Involved in regulation of protein-containing complex assembly and signal transduction. Located in cytosol; fungal-type vacuole; and vacuolar membrane. Part of nucleotide-activated protein kinase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SIP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1315326..1317773, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Hkr1p Neighboring gene Aro80p Neighboring gene Cad1p Neighboring gene dynein light chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and carbon source regulation of phosphorylation of Sip1p, a Snf1p-associated protein involved in carbon response in Saccharomyces cerevisiae. Long RM, et al. Yeast, 1995 Mar. PMID 7785324
  2. SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. Mylin LM, et al. Genetics, 1994 Jul. PMID 8088514, Free PMC Article
  3. Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protein kinase. Hedbacker K, et al. Mol Cell Biol, 2004 Mar. PMID 14966266, Free PMC Article
  4. The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis. Zhang J, et al. Mol Microbiol, 2010 Jul. PMID 20545859
  5. Beta-subunits of the SnRK1 complexes share a common ancestral function together with expression and function specificities; physical interaction with nitrate reductase specifically occurs via AKINbeta1-subunit. Polge C, et al. Plant Physiol, 2008 Nov. PMID 18768910, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mutant strain with only SIP1 expressed could utilize acetate, but neither ethanol nor glycerol.
    Title: The beta-subunits of the Snf1 kinase in Saccharomyces cerevisiae, Gal83 and Sip2, but not Sip1, are redundant in glucose derepression and regulation of sterol biosynthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to AMP-activated protein kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of protein-containing complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleotide-activated protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sip1p
NP_010710.4
  • One of three alternate beta-subunits of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1315326..1317773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180730.3 → NP_010710.4  TPA: Sip1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010710.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT52, P32578
    UniProtKB/TrEMBL
    C7GTM9
    Conserved Domains (2) summary
    smart01010
    Location:687 → 804
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    cl28984
    Location:504 → 562
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32578.2

Gene LinkOut

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