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ERD1 Erd1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852023, updated on 2-Nov-2024

Summary

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Official Symbol
ERD1
Official Full Name
Erd1p
Primary source
SGD:S000002822
Locus tag
YDR414C
See related
AllianceGenome:SGD:S000002822; FungiDB:YDR414C; VEuPathDB:YDR414C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LDB2
Summary
Involved in protein retention in ER lumen. Acts upstream of or within protein glycosylation and retrograde transport, vesicle recycling within Golgi. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERD1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1295598..1296686, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Dfm1p Neighboring gene Rrp17p Neighboring gene putative aminopeptidase Neighboring gene mRNA splicing protein SYF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sorting of soluble ER proteins in yeast. Pelham HR, et al. EMBO J, 1988 Jun. PMID 3049074, Free PMC Article
  2. Cloning and DNA sequence of a Kluyveromyces lactis ERD1 homologue. Dean N. Yeast, 1994 Aug. PMID 7992512
  3. ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus. Hardwick KG, et al. EMBO J, 1990 Mar. PMID 2178921, Free PMC Article
  4. δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and function. Arakel EC, et al. Proc Natl Acad Sci U S A, 2016 Jun 21. PMID 27298352, Free PMC Article
  5. Characterization of aromatic residue-controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae. Mei M, et al. J Biol Chem, 2017 Dec 15. PMID 29038295, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases.
    Title: Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases.
  2. Erd1 transports Pi in the opposite direction from XPR1 and other EXS family proteins and facilitates byproduct removal from the Golgi complex together with Gdt1
    Title: H(+) and Pi Byproducts of Glycosylation Affect Ca(2+) Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein retention in ER lumen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retrograde transport, vesicle recycling within Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Erd1p
NP_010702.4
  • Predicted membrane protein required for lumenal ER protein retention; Golgi inorganic phosphate (Pi) exporter that balances Pi import associated with NDP-sugar transport into the Golgi; involved in recycling of early glycosyltransferases from late to early Golgi compartments; mutants secrete the endogenous ER protein, BiP (Kar2p)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1295598..1296686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180722.4 → NP_010702.4  TPA: Erd1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010702.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT45, P16151
    UniProtKB/TrEMBL
    B3LFP1, B5VGU6, C7GY30, C8Z5X7, N1PAJ7
    Conserved Domains (1) summary
    cl03905
    Location:1 → 362
    EXS; EXS family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16151.3

Gene LinkOut

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