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DIT2 putative cytochrome P450 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852011, updated on 2-Nov-2024

Summary

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Official Symbol
DIT2
Official Full Name
putative cytochrome P450
Primary source
SGD:S000002810
Locus tag
YDR402C
See related
AllianceGenome:SGD:S000002810; FungiDB:YDR402C; VEuPathDB:YDR402C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CYP56
Summary
Enables NADPH dehydrogenase activity. Involved in ascospore wall assembly. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 5. Orthologous to human CYP4F22 (cytochrome P450 family 4 subfamily F member 22). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DIT2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1272234..1273703, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hypoxanthine phosphoribosyltransferase Neighboring gene trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase Neighboring gene Dit1p Neighboring gene DNA-directed RNA polymerase II subunit RPB7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of two developmentally regulated genes involved in spore wall maturation in Saccharomyces cerevisiae. Briza P, et al. Genes Dev, 1990 Oct. PMID 2249774
  2. Gene expression from random libraries of yeast promoters. Ligr M, et al. Genetics, 2006 Apr. PMID 16415362, Free PMC Article
  3. An Ssn6-Tup1-dependent negative regulatory element controls sporulation-specific expression of DIT1 and DIT2 in Saccharomyces cerevisiae. Friesen H, et al. Mol Cell Biol, 1997 Jan. PMID 8972192, Free PMC Article
  4. Studies on the Properties of the Sporulation Specific Protein Dit1 and its Product Formyl Tyrosine. Basiony M, et al. J Fungi (Basel), 2020 Jun 3. PMID 32503197, Free PMC Article
  5. Characterization of a yeast sporulation-specific P450 family protein, Dit2, using an in vitro assay to crosslink formyl tyrosine. Bemena LD, et al. J Biochem, 2018 Feb 1. PMID 29365103

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADPH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ascospore wall assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative cytochrome P450
NP_010690.1
  • N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1272234..1273703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180710.1 → NP_010690.1  TPA: putative cytochrome P450 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010690.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT34, P21595
    UniProtKB/TrEMBL
    G2WBE0, N1P7D5
    Conserved Domains (1) summary
    cd11070
    Location:65 → 485
    CYP56-like; cytochrome P450 family 56-like fungal cytochrome P450s
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21595.2

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