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NCB2 negative cofactor 2 transcription regulator complex subunit NCB2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852006, updated on 14-Nov-2024

Summary

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Official Symbol
NCB2
Official Full Name
negative cofactor 2 transcription regulator complex subunit NCB2
Primary source
SGD:S000002805
Locus tag
YDR397C
See related
AllianceGenome:SGD:S000002805; FungiDB:YDR397C; VEuPathDB:YDR397C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YDR1
Summary
Enables chromatin binding activity; core promoter sequence-specific DNA binding activity; and transcription corepressor activity. Contributes to TBP-class protein binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to heat; and regulation of DNA-templated transcription. Located in nucleus. Part of negative cofactor 2 complex. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NCB2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_001136.10 (1266366..1266898, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle base subunit RPT3 Neighboring gene Sxm1p Neighboring gene Utp5p Neighboring gene hypoxanthine phosphoribosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Kim S, et al. Proc Natl Acad Sci U S A, 1997 Feb 4. PMID 9023340, Free PMC Article
  2. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Gadbois EL, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096360, Free PMC Article
  3. The dual control of TFIIB recruitment by NC2 is gene specific. Masson P, et al. Nucleic Acids Res, 2008 Feb. PMID 18048413, Free PMC Article
  4. Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Cang Y, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12237409, Free PMC Article
  5. Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo. Geisberg JV, et al. Mol Cell Biol, 2001 Apr. PMID 11283253, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to TBP-class protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of RNA polymerase II transcription preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of negative cofactor 2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of negative cofactor 2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of negative cofactor 2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
negative cofactor 2 transcription regulator complex subunit NCB2
NP_010685.1
  • Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1266366..1266898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180705.1 → NP_010685.1  TPA: negative cofactor 2 transcription regulator complex subunit NCB2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010685.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT30, O00064, P87340, Q04176, Q92317
    UniProtKB/TrEMBL
    A6ZYZ7, B3LFQ4, C7GSC6, C8Z5W1, G2WBD6, N1P8T8
    Conserved Domains (1) summary
    COG5150
    Location:1 → 146
    COG5150; Class 2 transcription repressor NC2, beta subunit (Dr1) [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92317.1

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