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SAC7 GTPase-activating protein SAC7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851997, updated on 2-Nov-2024

Summary

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Official Symbol
SAC7
Official Full Name
GTPase-activating protein SAC7
Primary source
SGD:S000002797
Locus tag
YDR389W
See related
AllianceGenome:SGD:S000002797; FungiDB:YDR389W; VEuPathDB:YDR389W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activator activity. Involved in negative regulation of Rho protein signal transduction; regulation of actin cytoskeleton organization; and regulation of fungal-type cell wall organization. Located in cell cortex. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SAC7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1252537..1254501)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cin10p Neighboring gene amphiphysin Neighboring gene E1 ubiquitin-activating protein UBA2 Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae. Dunn TM, et al. Mol Cell Biol, 1990 May. PMID 2183030, Free PMC Article
  2. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Schmidt A, et al. Cell, 1997 Feb 21. PMID 9038344
  3. Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Lorberg A, et al. Mol Genet Genomics, 2001 Nov. PMID 11713681
  4. The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Schmidt A, et al. Mol Microbiol, 2002 Sep. PMID 12207708
  5. Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway. deHart AK, et al. Mol Biol Cell, 2003 Nov. PMID 14593073, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of fungal-type cell wall organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTPase-activating protein SAC7
NP_010677.1
  • GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1252537..1254501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180697.1 → NP_010677.1  TPA: GTPase-activating protein SAC7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010677.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VT23, P17121, Q04163
    UniProtKB/TrEMBL
    B3LFR1, C7GSD3, C8Z5V3, N1P5G3
    Conserved Domains (1) summary
    cd04396
    Location:122 → 393
    RhoGAP_fSAC7_BAG7; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17121.2

Gene LinkOut

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