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SEM1 proteasome regulatory particle lid subunit SEM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851967, updated on 2-Nov-2024

Summary

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Official Symbol
SEM1
Official Full Name
proteasome regulatory particle lid subunit SEM1
Primary source
SGD:S000007235
Locus tag
YDR363W-A
See related
AllianceGenome:SGD:S000007235; FungiDB:YDR363W-A; VEuPathDB:YDR363W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DSS1; HOD1
Summary
Involved in several processes, including SAGA complex localization to transcription regulatory region; mRNA export from nucleus; and maintenance of DNA trinucleotide repeats. Located in cytosol and proteasome storage granule. Part of proteasome regulatory particle, lid subcomplex and transcription export complex 2. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SEM1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1202128..1202397)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Esc2p Neighboring gene tRNA-Lys Neighboring gene Cdc40p Neighboring gene pre-rRNA-processing protein ESF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional inactivation of the conserved Sem1p in yeast by intrabodies. Reinman M, et al. Yeast, 2003 Sep. PMID 12961755
  2. Designed proteins to modulate cellular networks. Cortajarena AL, et al. ACS Chem Biol, 2010 Jun 18. PMID 20020775, Free PMC Article
  3. Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Marston NJ, et al. Mol Cell Biol, 1999 Jul. PMID 10373512, Free PMC Article
  4. Kluyveromyces lactis SSO1 and SEB1 genes are functional in Saccharomyces cerevisiae and enhance production of secreted proteins when overexpressed. Toikkanen JH, et al. Yeast, 2004 Sep. PMID 15449305
  5. Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation. Qin S, et al. Nucleic Acids Res, 2009 Apr. PMID 19188254, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sem1 has a distinct, chaperone-like function specific to early stages of proteasome assembly.
    Title: The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis.
  2. Results demonstrate that Sem1p and Ubp6p maintain telomeric heterochromatin structure through modulation of histone covalent modifications and association of silencing factors independently of the proteolytic function of the proteasome.
    Title: Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation.
  3. These data enabled the discovery of links between components of the mRNA export and splicing machineries and Sem1/Dss1, a component of the 19S proteasome.
    Title: A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SAGA complex localization to transcription regulatory region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filamentous growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus HGI PubMed 
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in maintenance of DNA trinucleotide repeats IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle, lid subcomplex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IEA
Inferred from Electronic Annotation
more info
  
located_in proteasome storage granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex 2 IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome regulatory particle lid subunit SEM1
NP_010651.3
  • 19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1202128..1202397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184328.3 → NP_010651.3  TPA: proteasome regulatory particle lid subunit SEM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010651.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSZ2, O94742
    UniProtKB/TrEMBL
    A6ZYW2, B3LFT9, C7GMH3, G2WBA0, N1P799
    Conserved Domains (1) summary
    cd13768
    Location:28 → 84
    DSS1_Sem1; proteasome complex subunit DSS1/Sem1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94742.1

Gene LinkOut

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