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CNL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851959, updated on 11-Sep-2024

Summary

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Official Symbol
CNL1
Primary source
SGD:S000002765
Locus tag
YDR357C
See related
AllianceGenome:SGD:S000002765; FungiDB:YDR357C; VEuPathDB:YDR357C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endosome organization and regulation of protein localization. Located in cytoplasm. Part of BLOC-1 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1189199..1189567, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene anthranilate phosphoribosyltransferase Neighboring gene Spc110p Neighboring gene ubiquitin-binding protein Neighboring gene Eaf1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae. Norambuena L, et al. BMC Chem Biol, 2008 Jan 7. PMID 18179719, Free PMC Article
  2. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Hayes MJ, et al. Traffic, 2011 Mar. PMID 21159114, Free PMC Article
  3. The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. John Peter AT, et al. J Cell Biol, 2013 Apr 1. PMID 23547030, Free PMC Article
  4. Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Rana M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971802, Free PMC Article
  5. RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. Wang G, et al. Proc Natl Acad Sci U S A, 2019 May 7. PMID 31000602, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BLOC-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of BLOC-1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of BLOC-1 complex ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cnl1p
NP_010644.1
  • Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1189199..1189567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180665.1 → NP_010644.1  TPA: Cnl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010644.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZYV6, B3LFU5, C7GMH9, C8Z5R9, D6VSY6, E7KB73, E7NG53, E7QDA1, Q06333
    UniProtKB/TrEMBL
    N1P5C4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06333.1

Gene LinkOut

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