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TRR1 thioredoxin-disulfide reductase TRR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851955, updated on 2-Nov-2024

Summary

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Official Symbol
TRR1
Official Full Name
thioredoxin-disulfide reductase TRR1
Primary source
SGD:S000002761
Locus tag
YDR353W
See related
AllianceGenome:SGD:S000002761; FungiDB:YDR353W; VEuPathDB:YDR353W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferrous iron binding activity and thioredoxin-disulfide reductase (NADPH) activity. Involved in cell redox homeostasis and cellular response to oxidative stress. Located in cytosol and mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TRR1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1183299..1184258)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sbe2p Neighboring gene Ypq2p Neighboring gene anthranilate phosphoribosyltransferase Neighboring gene Spc110p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Saccharomyces cerevisiae proteome of oxidized protein thiols: contrasted functions for the thioredoxin and glutathione pathways. Le Moan N, et al. J Biol Chem, 2006 Apr 14. PMID 16418165
  2. Time line of redox events in aging postmitotic cells. Brandes N, et al. Elife, 2013 Feb 5. PMID 23390587, Free PMC Article
  3. A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae. Kang HJ, et al. Biochem Biophys Res Commun, 2008 Jun 20. PMID 18406344
  4. Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems. Trotter EW, et al. EMBO Rep, 2003 Feb. PMID 12612609, Free PMC Article
  5. The human p53 negative regulatory domain mediates inhibition of reporter gene transactivation in yeast lacking thioredoxin reductase. Merrill GF, et al. Cancer Res, 1999 Jul 1. PMID 10397262

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endoplasmic reticulum stress-induced reactive oxygen species are detrimental for the fitness of a thioredoxin reductase mutant.
    Title: Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant.
  2. In searching for spontaneous suppressors of synthetic lethality of tsa1Delta rad51Delta double mutants, we identified that the loss of thioredoxin reductase Trr1 rescues their viability.
    Title: Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.
  3. The cytosolic thioredoxin-thioredoxin reductase system and not the glutaredoxins contributes to the reduction of GSSG
    Title: The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae.
  4. Results suggest that redox control via the thioredoxin-thioredoxin reductase 1/2 system plays an important role in the regulation of translation.
    Title: Activation of translation via reduction by thioredoxin-thioredoxin reductase in Saccharomyces cerevisiae.
  5. the crystal structure of Trr1 at the resolution of 2.8 A, the first fungal TrxR structure
    Title: Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin.
  6. The iron-binding activity of thioredoxin reductase was identified.
    Title: A novel role for thioredoxin reductase in the iron metabolism of S. cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thioredoxin-disulfide reductase TRR1
NP_010640.1
  • Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1183299..1184258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180661.1 → NP_010640.1  TPA: thioredoxin-disulfide reductase TRR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSY3, P29509
    UniProtKB/TrEMBL
    A6ZYV3, B3LFU8, B5VGN5, C7GMI1, C8Z5R4, G2WB91, N1P789
    Conserved Domains (1) summary
    TIGR01292
    Location:5 → 315
    TRX_reduct; thioredoxin-disulfide reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29509.3

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