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YPQ2 Ypq2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851954, updated on 18-Sep-2024

Summary

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Official Symbol
YPQ2
Official Full Name
Ypq2p
Primary source
SGD:S000002760
Locus tag
YDR352W
See related
AllianceGenome:SGD:S000002760; FungiDB:YDR352W; VEuPathDB:YDR352W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane export from vacuole. Acts upstream of or within basic amino acid transmembrane import into vacuole. Is integral component of fungal-type vacuolar membrane. Orthologous to several human genes including SLC66A1 (solute carrier family 66 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPQ2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1181801..1182754)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atp22p Neighboring gene Sbe2p Neighboring gene thioredoxin-disulfide reductase TRR1 Neighboring gene anthranilate phosphoribosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A PQ-loop protein Ypq2 is involved in the exchange of arginine and histidine across the vacuolar membrane of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Sci Rep, 2019 Oct 21. PMID 31636363, Free PMC Article
  2. Nitrogen coordinated import and export of arginine across the yeast vacuolar membrane. Cools M, et al. PLoS Genet, 2020 Aug. PMID 32776922, Free PMC Article
  3. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Manabe K, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26928127
  4. The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. Llinares E, et al. Sci Rep, 2015 Nov 18. PMID 26577948, Free PMC Article
  5. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Jézégou A, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23169667, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables basic amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables basic amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transmembrane export from vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basic amino acid transmembrane export from vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within basic amino acid transmembrane import into vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ypq2p
NP_010639.1
  • Putative vacuolar membrane transporter for cationic amino acids; involved in vacuolar export of arginine under nitrogen starvation conditions; appears to be inactive under nitrogen replete conditions; may contribute to amino acid homeostasis; vacuolar membrane protein; member of the PQ-loop family, containing seven transmembrane domains; homologous to the human lysosomal cationic amino acid exporter PQLC2; null mutant is functionally complemented by the rat PQLC2 vacuolar transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1181801..1182754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180660.1 → NP_010639.1  TPA: Ypq2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010639.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSY2, Q06328
    UniProtKB/TrEMBL
    B3LFU9, B5VGN4, C7GMI2, C8Z5R3, N1PAI4
    Conserved Domains (1) summary
    pfam04193
    Location:11 → 71
    PQ-loop; PQ loop repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06328.1

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