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PAL1 Pal1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851949, updated on 3-Nov-2024

Summary

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Official Symbol
PAL1
Official Full Name
Pal1p
Primary source
SGD:S000002756
Locus tag
YDR348C
See related
AllianceGenome:SGD:S000002756; FungiDB:YDR348C; VEuPathDB:YDR348C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in endocytosis. Located in actin cortical patch. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PAL1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1170326..1171825, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Svf1p Neighboring gene mitochondrial 37S ribosomal protein MRP1 Neighboring gene putative aspartic endopeptidase Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Profiling and verifying the substrates of E3 ubiquitin ligase Rsp5 in yeast cells. Fang S, et al. STAR Protoc, 2023 Sep 15. PMID 37561636, Free PMC Article
  2. Identification of Suppressor of Clathrin Deficiency-1 (SCD1) and Its Connection to Clathrin-Mediated Endocytosis in Saccharomyces cerevisiae. Moorthy BT, et al. G3 (Bethesda), 2019 Mar 7. PMID 30679249, Free PMC Article
  3. Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer. Wang Y, et al. Cell Chem Biol, 2021 Sep 16. PMID 33667410, Free PMC Article
  4. Analysis of yeast endocytic site formation and maturation through a regulatory transition point. Carroll SY, et al. Mol Biol Cell, 2012 Feb. PMID 22190733, Free PMC Article
  5. The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast. Sun Y, et al. PLoS Biol, 2024 Sep. PMID 39316607, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud tip HDA PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mating projection tip HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pal1p
NP_010635.1
  • hypothetical protein thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1170326..1171825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180656.1 → NP_010635.1  TPA: Pal1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010635.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSX8, Q05518, Q66RD5
    UniProtKB/TrEMBL
    A6ZYU8, B3LFV2, C8Z5Q9, N1PAI3
    Conserved Domains (1) summary
    pfam08316
    Location:236 → 369
    Pal1; Pal1 cell morphology protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05518.1

Gene LinkOut

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