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HXT3 hexose transporter HXT3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851946, updated on 14-Nov-2024

Summary

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Official Symbol
HXT3
Official Full Name
hexose transporter HXT3
Primary source
SGD:S000002753
Locus tag
YDR345C
See related
AllianceGenome:SGD:S000002753; FungiDB:YDR345C; VEuPathDB:YDR345C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-glucose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HXT3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1162957..1164660, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT6 Neighboring gene uncharacterized protein Neighboring gene Svf1p Neighboring gene mitochondrial 37S ribosomal protein MRP1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering of an endogenous hexose transporter into a specific D-xylose transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae. Nijland JG, et al. Biotechnol Biofuels, 2014. PMID 25505932, Free PMC Article
  2. Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Kim JH, et al. Mol Cell Biol, 2003 Aug. PMID 12861007, Free PMC Article
  3. Downshifting Yeast Dominance: Cell Physiology and Phospholipid Composition Are Altered With Establishment of the [GAR (+)] Prion in Saccharomyces cerevisiae. Walker GA, et al. Front Microbiol, 2020. PMID 32983023, Free PMC Article
  4. Modeling simultaneous glucose and xylose uptake in Saccharomyces cerevisiae from kinetics and gene expression of sugar transporters. Bertilsson M, et al. Bioprocess Biosyst Eng, 2008 Jun. PMID 17985160
  5. Reduction of glucose uptake through inhibition of hexose transporters and enhancement of their endocytosis by methylglyoxal in Saccharomyces cerevisiae. Yoshida A, et al. J Biol Chem, 2012 Jan 2. PMID 22094464, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
    Title: Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables mannose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hexose transporter HXT3
NP_010632.1
  • Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1162957..1164660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180653.1 → NP_010632.1  TPA: hexose transporter HXT3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010632.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSX5, P32466
    UniProtKB/TrEMBL
    A6ZYU5, B3LFV5, E9P9G8, N1P8P4
    Conserved Domains (1) summary
    pfam00083
    Location:65 → 525
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32466.1

Gene LinkOut

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