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HXT6 hexose transporter HXT6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851944, updated on 14-Nov-2024

Summary

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Official Symbol
HXT6
Official Full Name
hexose transporter HXT6
Primary source
SGD:S000002751
Locus tag
YDR343C
See related
AllianceGenome:SGD:S000002751; FungiDB:YDR343C; VEuPathDB:YDR343C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-glucose transmembrane transporter activity. Predicted to be involved in carbohydrate transport. Located in mitochondrial membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HXT6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1159608..1161320, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene arginine--tRNA ligase Neighboring gene hexose transporter HXT7 Neighboring gene uncharacterized protein Neighboring gene hexose transporter HXT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering of an endogenous hexose transporter into a specific D-xylose transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae. Nijland JG, et al. Biotechnol Biofuels, 2014. PMID 25505932, Free PMC Article
  2. Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited environment. Brown CJ, et al. Mol Biol Evol, 1998 Aug. PMID 9718721
  3. Starvation-induced degradation of yeast hexose transporter Hxt7p is dependent on endocytosis, autophagy and the terminal sequences of the permease. Krampe S, et al. FEBS Lett, 2002 Feb 27. PMID 11904149
  4. Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae. Prada-Luengo I, et al. Nucleic Acids Res, 2020 Aug 20. PMID 32609810, Free PMC Article
  5. The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment. Chiotti KE, et al. Genomics, 2014 Dec. PMID 25449178, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two glucose signaling pathways converge onto Csr2 to regulate hexose transporter Hxt6 endocytosis by glucose availability.
    Title: Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.
  2. demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2
    Title: Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.
  3. Variation in the copy number of HXT6/HTX7 locus was observed in a survey of ~70 yeast strains.
    Title: Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.
  4. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here.
    Title: Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables mannose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hexose transporter HXT6
NP_010630.1
  • High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1159608..1161320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180651.1 → NP_010630.1  TPA: hexose transporter HXT6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010630.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSX4, P39003
    UniProtKB/TrEMBL
    E9P9G7
    Conserved Domains (2) summary
    cd06174
    Location:69 → 514
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:68 → 528
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39003.2

Gene LinkOut

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