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FCF1 rRNA-processing protein FCF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851939, updated on 2-Nov-2024

Summary

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Official Symbol
FCF1
Official Full Name
rRNA-processing protein FCF1
Primary source
SGD:S000002747
Locus tag
YDR339C
See related
AllianceGenome:SGD:S000002747; FungiDB:YDR339C; VEuPathDB:YDR339C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
UTP24
Summary
Enables RNA endonuclease activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human FCF1 (FCF1 rRNA-processing protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FCF1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1149951..1150520, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRPS28 Neighboring gene uncharacterized protein Neighboring gene tRNA-Ser Neighboring gene arginine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0. Tomecki R, et al. RNA Biol, 2015. PMID 26237581, Free PMC Article
  2. The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans. Wells GR, et al. Nucleic Acids Res, 2016 Jun 20. PMID 27034467, Free PMC Article
  3. Structural and functional analysis of Utp24, an endonuclease for processing 18S ribosomal RNA. An W, et al. PLoS One, 2018. PMID 29641590, Free PMC Article
  4. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
  5. The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Wells GR, et al. Nucleic Acids Res, 2017 May 5. PMID 28082392, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Utp24 might be the elusive endonuclease that cleaves the pre-rRNA at sites A(1) and/or A(2.)[Utp24]
    Title: The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.
  2. localized to the nucleolus; involved in pre-rRNA processing
    Title: Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
rRNA-processing protein FCF1
NP_010626.1
  • PINc domain endonuclease; required for early cleavage of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1149951..1150520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180647.1 → NP_010626.1  TPA: rRNA-processing protein FCF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010626.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSX1, Q05498
    UniProtKB/TrEMBL
    A6ZYU1, B3LFV8, B5VGM2, C7GWN6, C8Z5Q1, G2WB79, N1PAI2
    Conserved Domains (1) summary
    cd09864
    Location:53 → 183
    PIN_Fcf1-like; VapC-like PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05498.1

Gene LinkOut

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