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IPK1 inositol pentakisphosphate 2-kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851910, updated on 18-Sep-2024

Summary

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Official Symbol
IPK1
Official Full Name
inositol pentakisphosphate 2-kinase
Primary source
SGD:S000002723
Locus tag
YDR315C
See related
AllianceGenome:SGD:S000002723; FungiDB:YDR315C; VEuPathDB:YDR315C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GSL1
Summary
Enables inositol pentakisphosphate 2-kinase activity. Involved in inositol phosphate biosynthetic process and nuclear-transcribed mRNA catabolic process, non-stop decay. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IPK1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1092741..1093586, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase Neighboring gene Rad34p Neighboring gene putative RNA methyltransferase Neighboring gene tRNA-Phe

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential expression of structural genes for the late phase of phytic acid biosynthesis in developing seeds of wheat (Triticum aestivum L.). Bhati KK, et al. Plant Sci, 2014 Jul. PMID 24908508
  2. Molecular and biochemical identification of inositol 1,3,4,5,6-pentakisphosphate 2-kinase encoding mRNA variants in castor bean (Ricinus communis L.) seeds. Yu J, et al. Planta, 2014 May. PMID 24463774
  3. Dual functions for the Schizosaccharomyces pombe inositol kinase Ipk1 in nuclear mRNA export and polarized cell growth. Sarmah B, et al. Eukaryot Cell, 2009 Feb. PMID 19047361, Free PMC Article
  4. Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Sweetman D, et al. Biochem J, 2006 Feb 15. PMID 16223361, Free PMC Article
  5. Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1. Dossani ZY, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805289, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol pentakisphosphate 2-kinase
NP_010601.3
  • Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1092741..1093586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180623.3 → NP_010601.3  TPA: inositol pentakisphosphate 2-kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010601.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSU4, Q06667
    UniProtKB/TrEMBL
    A6ZYR3, C7GWL2, C8Z5M6, N1P8M0
    Conserved Domains (1) summary
    pfam06090
    Location:4 → 265
    Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06667.1

Gene LinkOut

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