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RNH202 Rnh202p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851873, updated on 18-Sep-2024

Summary

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Official Symbol
RNH202
Official Full Name
Rnh202p
Primary source
SGD:S000002687
Locus tag
YDR279W
See related
AllianceGenome:SGD:S000002687; FungiDB:YDR279W; VEuPathDB:YDR279W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to RNA-DNA hybrid ribonuclease activity. Involved in RNA catabolic process. Located in nucleus. Part of ribonuclease H2 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RNH202 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1019368..1020420)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mth1p Neighboring gene tRNA-Glu Neighboring gene exosome non-catalytic core subunit RRP45 Neighboring gene Phm6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome instability consequences of RNase H2 Aicardi-Goutières syndrome alleles. Potenski CJ, et al. DNA Repair (Amst), 2019 Dec. PMID 30975634, Free PMC Article
  2. RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Jeong HS, et al. Nucleic Acids Res, 2004. PMID 14734815, Free PMC Article
  3. RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Lockhart A, et al. Cell Rep, 2019 Nov 26. PMID 31775053
  4. RNase H2 roles in genome integrity revealed by unlinking its activities. Chon H, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23355612, Free PMC Article
  5. Analysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex. Nguyen TA, et al. FEBS J, 2011 Dec. PMID 22004424

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA-DNA hybrid ribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA-DNA hybrid ribonuclease activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease H2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonuclease H2 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rnh202p
NP_010565.3
  • Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    1019368..1020420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180587.3 → NP_010565.3  TPA: Rnh202p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010565.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSQ9, Q05635, Q6Q5R1
    UniProtKB/TrEMBL
    A6ZYM8, B3LG15, B5VGF8, C8Z5J2, N1P6S2
    Conserved Domains (1) summary
    cd09270
    Location:12 → 348
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05635.1

Gene LinkOut

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