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MNN10 alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 851832, updated on 18-Sep-2024

Summary

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Official Symbol
MNN10
Official Full Name
alpha-1,6-mannosyltransferase
Primary source
SGD:S000002653
Locus tag
YDR245W
See related
AllianceGenome:SGD:S000002653; FungiDB:YDR245W; VEuPathDB:YDR245W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BED1; REC41; SLC2
Summary
Enables alpha-1,6-mannosyltransferase activity. Involved in cell wall mannoprotein biosynthetic process; division septum assembly; and protein N-linked glycosylation. Located in endoplasmic reticulum. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MNN10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (952800..953981)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein PRP28 Neighboring gene Pex5p Neighboring gene TRAPP subunit TRS23 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular and phenotypic analysis of the S. cerevisiae MNN10 gene identifies a family of related glycosyltransferases. Dean N, et al. Glycobiology, 1996 Jan. PMID 8991513
  2. BED1, a gene encoding a galactosyltransferase homologue, is required for polarized growth and efficient bud emergence in Saccharomyces cerevisiae. Mondésert G, et al. J Cell Biol, 1996 Jan. PMID 8567719, Free PMC Article
  3. [Rec41--a new gene, participating in the control of recombination in Saccharomyces cerevisiae yeast]. Chepurnaia OV, et al. Genetika, 1993 Feb. PMID 8486254
  4. Importance of cell wall mannoproteins for septum formation in Saccharomyces cerevisiae. Schmidt M, et al. Yeast, 2005 Jul 15. PMID 16034811
  5. Disruption of the MNN10 gene enhances protein secretion in Kluyveromyces lactis and Saccharomyces cerevisiae. Bartkeviciūte D, et al. FEMS Yeast Res, 2004 Sep. PMID 15450190

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall mannoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mannan polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,6-mannosyltransferase
NP_010531.1
  • Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    952800..953981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180553.1 → NP_010531.1  TPA: alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010531.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSM5, P50108
    UniProtKB/TrEMBL
    A6ZYJ7, B3LG44, B5VGD1, C7GTI0, C8Z5F6, G2WAY8, N1P6Y1
    Conserved Domains (1) summary
    pfam05637
    Location:118 → 368
    Glyco_transf_34; galactosyl transferase GMA12/MNN10 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50108.1

Gene LinkOut

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