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RAV2 Rav2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851784, updated on 18-Sep-2024

Summary

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Official Symbol
RAV2
Official Full Name
Rav2p
Primary source
SGD:S000002610
Locus tag
YDR202C
See related
AllianceGenome:SGD:S000002610; FungiDB:YDR202C; VEuPathDB:YDR202C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in regulation of protein-containing complex assembly and vacuolar acidification. Part of RAVE complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RAV2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (856898..857953, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vps64p Neighboring gene Spc19p Neighboring gene ubiquinone biosynthesis protein COQ4 Neighboring gene metal cation transporter MSC2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the complex involved in regulating V-ATPase activity of the vacuolar and endosomal membrane. Zhang Z, et al. J Bioenerg Biomembr, 2017 Oct. PMID 28643238
  2. Molecular Interactions and Cellular Itinerary of the Yeast RAVE (Regulator of the H+-ATPase of Vacuolar and Endosomal Membranes) Complex. Smardon AM, et al. J Biol Chem, 2015 Nov 13. PMID 26405040, Free PMC Article
  3. RAVE is essential for the efficient assembly of the C subunit with the vacuolar H(+)-ATPase. Smardon AM, et al. J Biol Chem, 2007 Sep 7. PMID 17623654
  4. Interaction between the yeast RAVE complex and Vph1-containing V(o) sectors is a central glucose-sensitive interaction required for V-ATPase reassembly. Jaskolka MC, et al. J Biol Chem, 2020 Feb 21. PMID 31941791, Free PMC Article
  5. Defining steps in RAVE-catalyzed V-ATPase assembly using purified RAVE and V-ATPase subcomplexes. Jaskolka MC, et al. J Biol Chem, 2021 Jan-Jun. PMID 33895134, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein-containing complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein-containing complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vacuolar acidification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RAVE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RAVE complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rav2p
NP_010488.1
  • Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    856898..857953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180510.1 → NP_010488.1  TPA: Rav2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010488.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSI4, Q03956
    UniProtKB/TrEMBL
    A6ZYG0, B3LG82, B5VG94, C7GMZ6, C8Z5B7, G2WAV0, N1P4Y3
    Conserved Domains (1) summary
    pfam10259
    Location:26 → 341
    Rogdi_lz; Rogdi leucine zipper containing protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03956.1

Gene LinkOut

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