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HST4 NAD-dependent histone deacetylase HST4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851772, updated on 14-Nov-2024

Summary

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Official Symbol
HST4
Official Full Name
NAD-dependent histone deacetylase HST4
Primary source
SGD:S000002599
Locus tag
YDR191W
See related
AllianceGenome:SGD:S000002599; FungiDB:YDR191W; VEuPathDB:YDR191W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NAD-dependent histone deacetylase activity. Involved in several processes, including mRNA transcription; replication-born double-strand break repair via sister chromatid exchange; and subtelomeric heterochromatin formation. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HST4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (842337..843449)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene syntaxin-binding protein Neighboring gene RuvB family ATP-dependent DNA helicase pontin Neighboring gene FG-nucleoporin NUP42 Neighboring gene ATP-dependent RNA helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance. Gershon L, et al. Genes (Basel), 2021 Feb 25. PMID 33668997, Free PMC Article
  2. Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae. Hachinohe M, et al. Genes Cells, 2011 Apr. PMID 21401809
  3. Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p. Madsen CT, et al. Nat Commun, 2015 Jul 9. PMID 26158509, Free PMC Article
  4. Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability. Feldman JL, et al. Cell Rep, 2019 Jun 4. PMID 31167142, Free PMC Article
  5. The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Celic I, et al. Curr Biol, 2006 Jul 11. PMID 16815704

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance.
    Title: The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance.
  2. A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.
    Title: A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.
  3. This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so
    Title: Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation.
  4. Hst4p plays a pivotal role in biotin metabolism and cellular energy homeostasis, and data supports that Hst4p is a functional yeast homologue of the sirtuin deacetylase SIRT3.
    Title: Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p.
  5. Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability.
    Title: Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae.
  6. HST3 HST4 play critical roles in maintaining the hypoacetylated state of lysine56 on histone H3 within silent chromatin.
    Title: HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.
  7. cells lacking Hst4p, in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA damage
    Title: Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.
  8. That acetylation of Histone H3 by Hst4 takes place during checkpoint regulation was determined.
    Title: Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.
  9. Specific functions were found for HST4.
    Title: Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD-dependent protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K14 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K18 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K4 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K56 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone H4K16 deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity, NAD-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity, NAD-dependent IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication-born double-strand break repair via sister chromatid exchange IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in short-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating-type region heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAD-dependent histone deacetylase HST4
NP_010477.3
  • NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    842337..843449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180499.3 → NP_010477.3  TPA: NAD-dependent histone deacetylase HST4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010477.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSH4, P53688
    UniProtKB/TrEMBL
    B3LG92, B5VG85, C7GN06, C8Z5A6, N1P6I5
    Conserved Domains (1) summary
    COG0846
    Location:77 → 370
    SIR2; NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53688.1

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