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RVB1 RuvB family ATP-dependent DNA helicase pontin [ Saccharomyces cerevisiae S288C ]

Gene ID: 851771, updated on 2-Nov-2024

Summary

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Official Symbol
RVB1
Official Full Name
RuvB family ATP-dependent DNA helicase pontin
Primary source
SGD:S000002598
Locus tag
YDR190C
See related
AllianceGenome:SGD:S000002598; FungiDB:YDR190C; VEuPathDB:YDR190C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TIH1; TIP49; TIP49A
Summary
Enables 5'-3' DNA helicase activity. Contributes to 3'-5' DNA helicase activity. Involved in box C/D snoRNP assembly; chromatin remodeling; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of Ino80 complex; R2TP complex; and Swr1 complex. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RVB1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (840604..841995, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT6 Neighboring gene syntaxin-binding protein Neighboring gene NAD-dependent histone deacetylase HST4 Neighboring gene FG-nucleoporin NUP42

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins. King TH, et al. Mol Cell Biol, 2001 Nov. PMID 11604509, Free PMC Article
  2. Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping. Rizzolo K, et al. Cell Rep, 2017 Sep 12. PMID 28903051
  3. Functional and comparative characterization of Saccharomyces cerevisiae RVB1 and RVB2 genes with bacterial Ruv homologues. Radovic S, et al. FEMS Yeast Res, 2007 Jun. PMID 17302941
  4. Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex. Gribun A, et al. J Mol Biol, 2008 Mar 7. PMID 18234224
  5. Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy. Ewens CA, et al. Structure, 2016 May 3. PMID 27112599

See all (158) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation.
    Title: Rvb1/Rvb2 proteins couple transcription and translation during glucose starvation.
  2. results demonstrate the chaperone-like potential of Rvb1/Rvb2 and suggest a model where binding of multiple clients such as Ino80 stimulates ATP-driven cycling between hexamers and dodecamers, providing iterative opportunities for correct subunit assembly.
    Title: Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones.
  3. Data show that the 14 different polypeptide containing chromatin-remodeling complex SWR1 contains a single heterohexameric Rvb1/Rvb2 ring that, together with the catalytic subunit Swr1, brackets two independently assembled multisubunit modules.
    Title: Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1.
  4. purified endogenous untagged Rvb1/Rvb2 complexes were found as single hexameric rings, similar to the complexes assembled in vitro from purified untagged components
    Title: Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags.
  5. Pontin and reptin could acquire distinct structural states to regulate their broad functions as molecular motors and scaffolds for nucleic acids and proteins.
    Title: Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes.
  6. These results clearly establish the yeast Rvb1/2 complex as a heterohexameric ATP-dependent DNA helicase and highlight the possible roles played by the Rvb proteins within multiprotein complexes.
    Title: Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex.
  7. Rvb2p preferentially binds artificial DNA Holiday junctions like the bacterial RuvAB complex, whereas Rvb1p binds to duplex or cruciform DNA; both proteins also interact with chromatin and play a role in recombination and repair by chromatin remodelling.
    Title: Functional and comparative characterization of Saccharomyces cerevisiae RVB1 and RVB2 genes with bacterial Ruv homologues.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-3' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in box C/D snoRNP assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of R2TP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of R2TP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Swr1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RuvB family ATP-dependent DNA helicase pontin
NP_010476.1
  • ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    840604..841995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180498.1 → NP_010476.1  TPA: RuvB family ATP-dependent DNA helicase pontin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010476.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSH3, Q03940
    UniProtKB/TrEMBL
    A6ZYE9, B3LG93, B5VG84, C7GN07, C8Z5A5, G2WAT9, N1P8D2
    Conserved Domains (1) summary
    COG1224
    Location:4 → 463
    TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03940.1

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