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UPS3 Ups3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851766, updated on 29-Jun-2024

Summary

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Gene symbol
UPS3
Gene description
Ups3p
Primary source
FungiDB:YDR185C
Locus tag
YDR185C
See related
SGD:S000002593; AllianceGenome:SGD:S000002593; VEuPathDB:YDR185C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GEP2
Summary
Predicted to enable phosphatidic acid transfer activity. Involved in mitochondrion morphogenesis. Located in mitochondrial intermembrane space. Is extrinsic component of mitochondrial inner membrane. Orthologous to human PRELID3A (PRELI domain containing 3A) and PRELID3B (PRELI domain containing 3B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See UPS3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (831934..832473, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Plp1p Neighboring gene Atc1p Neighboring gene Snd1p Neighboring gene chaperonin-containing T-complex subunit CCT6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria. Hall BM, et al. J Biol Chem, 2011 Nov 11. PMID 21930701, Free PMC Article
  2. Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. Sesaki H, et al. J Cell Biol, 2006 Jun 5. PMID 16754953, Free PMC Article
  3. Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. Tamura Y, et al. EMBO J, 2010 Sep 1. PMID 20622808, Free PMC Article
  4. The GOLD domain, a novel protein module involved in Golgi function and secretion. Anantharaman V, et al. Genome Biol, 2002. PMID 12049664, Free PMC Article
  5. Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. Tamura Y, et al. J Cell Biol, 2009 Jun 15. PMID 19506038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
    Title: Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidic acid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ups3p
NP_010471.1
  • Mitochondrial hypothetical protein; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog, UPS2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    831934..832473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180493.1 → NP_010471.1  TPA: Ups3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010471.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSG9, Q04006
    UniProtKB/TrEMBL
    A0A6A5Q2I4, A6ZYE5, B3LG96, B5VG79, C7GN11, C8Z5A0, G2WAT5, N1P6H9
    Conserved Domains (1) summary
    pfam04707
    Location:15 → 171
    PRELI; PRELI-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04006.1

Gene LinkOut

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