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CDC1 putative lipid phosphatase CDC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851763, updated on 2-Nov-2024

Summary

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Official Symbol
CDC1
Official Full Name
putative lipid phosphatase CDC1
Primary source
SGD:S000002590
Locus tag
YDR182W
See related
AllianceGenome:SGD:S000002590; FungiDB:YDR182W; VEuPathDB:YDR182W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DSC1; DSR1; ESP2
Summary
Predicted to enable hydrolase activity and metal ion binding activity. Involved in DNA repair. Acts upstream of or within GPI anchor biosynthetic process. Located in endoplasmic reticulum. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CDC1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (827582..829057)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene cohesin-loading factor complex subunit SCC2 Neighboring gene Sas4p Neighboring gene uncharacterized protein Neighboring gene Plp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cell-cycle-regulated trans-factor, DSC1, controls expression of DNA synthesis genes in yeast. Johnston LH, et al. Cold Spring Harb Symp Quant Biol, 1991. PMID 1819484
  2. Mutations in the Saccharomyces cerevisiae CDC1 gene affect double-strand-break-induced intrachromosomal recombination. Halbrook J, et al. Mol Cell Biol, 1994 Dec. PMID 7969142, Free PMC Article
  3. The frost gene of Neurospora crassa is a homolog of yeast cdc1 and affects hyphal branching via manganese homeostasis. Sone T, et al. Fungal Genet Biol, 1999 Dec. PMID 10669587
  4. Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+. Lowndes NF, et al. Nature, 1992 Jan 30. PMID 1734281
  5. A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins. Morgan BA, et al. EMBO J, 1995 Nov 15. PMID 8521825, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc1 removes the ethanolamine phosphate of the first mannose of glycosylphosphatidylinositol anchors and thereby facilitates the integration of glycosylphosphatidylinositol proteins into the yeast cell wall.
    Title: Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall.
  2. Cdc1p is an endoplasmic reticulum-localized transmembrane protein with a putative phosphoesterase domain facing the lumen. cdc1 mutant cells accumulate an unidentified phospholipid, suggesting that Cdc1p may be a lipid phosphatase.
    Title: Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative lipid phosphatase CDC1
NP_010468.1
  • Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    827582..829057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180490.1 → NP_010468.1  TPA: putative lipid phosphatase CDC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010468.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSG5, P40986
    UniProtKB/TrEMBL
    B3LGA0, B5VG76, C7GN14, C8Z596, G2WAT1
    Conserved Domains (1) summary
    cd08163
    Location:91 → 347
    MPP_Cdc1; Saccharomyces cerevisiae CDC1 and related proteins, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40986.2

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