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SAC3 Sac3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851737, updated on 3-Nov-2024

Summary

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Official Symbol
SAC3
Official Full Name
Sac3p
Primary source
SGD:S000002566
Locus tag
YDR159W
See related
AllianceGenome:SGD:S000002566; FungiDB:YDR159W; VEuPathDB:YDR159W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LEP1
Summary
Involved in several processes, including mRNA metabolic process; nuclear export; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Part of nuclear pore cytoplasmic filaments and transcription export complex 2. Orthologous to several human genes including SAC3D1 (SAC3 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SAC3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (771877..775782)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase I subunit RPA14 Neighboring gene uncharacterized protein Neighboring gene aspartate-semialdehyde dehydrogenase Neighboring gene Ssy1p Neighboring gene Acl4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex. Gordon JMB, et al. Nucleic Acids Res, 2017 May 19. PMID 28334829, Free PMC Article
  2. Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2. Dimitrova L, et al. Structure, 2015 Jul 7. PMID 26051714, Free PMC Article
  3. The SAC3 gene encodes a nuclear protein required for normal progression of mitosis. Bauer A, et al. J Cell Sci, 1996 Jun. PMID 8799844
  4. Characterization of the SAC3 gene of Saccharomyces cerevisiae. Bauer A, et al. Yeast, 1996 Aug. PMID 8873450
  5. The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. Baker KE, et al. RNA, 2004 Sep. PMID 15273328, Free PMC Article

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the TREX-2 complex the TPR-like repeat region of the Sac3 chain extends further towards the N-terminus than had been previously thought.
    Title: The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region.
  2. Study finds that the TREX-2 complex (1) interacts with the Mediator Med31 submodule via the Sac3 PCI domain, (2) regulates Mediator association with the Cdk8 kinase, (3) impacts on Pol II carboxyl terminus domain Ser5 phosphorylation, and (4) employs a similar, conserved Sac3 PCI domain surface to promote transcription and mRNA export.
    Title: The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.
  3. Data show that the Sus1-binding site on Sgf11 is somewhat shorter than on Sac3 and is based on a narrower hydrophobic stripe.
    Title: Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
  4. Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process
    Title: The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament-based process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription export complex 2 IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex 2 IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sac3p
NP_010443.3
  • mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    771877..775782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180466.3 → NP_010443.3  TPA: Sac3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010443.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSD9, P46674
    UniProtKB/TrEMBL
    B3LGC5, C7GX39
    Conserved Domains (1) summary
    COG5079
    Location:103 → 812
    SAC3; Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46674.2

Gene LinkOut

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