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DOP1 Dop1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851719, updated on 2-Nov-2024

Summary

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Official Symbol
DOP1
Official Full Name
Dop1p
Primary source
SGD:S000002548
Locus tag
YDR141C
See related
AllianceGenome:SGD:S000002548; FungiDB:YDR141C; VEuPathDB:YDR141C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cell morphogenesis; retrograde transport, endosome to Golgi; and retrograde transport, vesicle recycling within Golgi. Located in endosome and trans-Golgi network. Orthologous to human DOP1A (DOP1 leucine zipper like protein A) and DOP1B (DOP1 leucine zipper like protein B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DOP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (734901..739997, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene NEDD8 family protein RUB1 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Pex7p Neighboring gene ubiquitin-protein ligase SAN1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network. Zhao SB, et al. Biochim Biophys Acta Gen Subj, 2019 Jun. PMID 30981741
  2. C21orf5, a new member of Dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in Down syndrome. Rachidi M, et al. DNA Res, 2005. PMID 16303751
  3. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Pascon RC, et al. Mol Microbiol, 2000 Jun. PMID 10931277
  4. Mon2 is a negative regulator of the monomeric G protein, Arl1. Manlandro CM, et al. FEMS Yeast Res, 2012 Sep. PMID 22594927
  5. Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Barbosa S, et al. Traffic, 2010 Aug. PMID 20477991

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate that Dop1 is involved in vesicular transport at the TGN, and is critical for retrieving glycosyltransferases from the TGN to the Golgi in yeast.
    Title: Yeast Dop1 is required for glycosyltransferase retrieval from the trans-Golgi network.
  2. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
    Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
  3. Dop1 plays a widespread role in membrane organization, and Mon2 acts as a scaffold to recruit the Golgi-localized pool of Dop1
    Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, vesicle recycling within Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dop1p
NP_010425.1
  • Protein involved in vesicular transport at trans-Golgi network (TGN); TGN-localized, leucine-zipper domain protein; involved in endosome-to-Golgi transport during endocytic recycling, and retrograde transport of glycosyltransferases from the TGN to the Golgi; involved in organization of the ER, establishment of cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    734901..739997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180448.1 → NP_010425.1  TPA: Dop1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010425.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSC4, Q03921
    UniProtKB/TrEMBL
    C7GIP6, G2WAP1, N1P897
    Conserved Domains (1) summary
    COG5221
    Location:6 → 1698
    DOP1; Dopey and related predicted leucine zipper transcription factors [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03921.1

Gene LinkOut

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