SAC6 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SAC6
Primary source: FungiDB:YDR129C
Locus tag: YDR129C
See related: SGD:S000002536; AllianceGenome:SGD:S000002536; VEuPathDB:YDR129C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ABP67
Summary: Enables actin filament binding activity and protein-macromolecule adaptor activity. Involved in formin-nucleated actin cable assembly. Located in actin cortical patch and actin filament bundle. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76 and osteoporosis. Orthologous to several human genes including LCP1 (lymphocyte cytosolic protein 1) and PLS3 (plastin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

SAC6 protein mutant was found to be defective in apical actin patch localization.
Title: Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in formin-nucleated actin cable assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in formin-nucleated actin cable assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament bundle	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mating projection tip	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

NP_010414.3

Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant

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