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MTC5 Mtc5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851706, updated on 3-Nov-2024

Summary

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Official Symbol
MTC5
Official Full Name
Mtc5p
Primary source
SGD:S000002535
Locus tag
YDR128W
See related
AllianceGenome:SGD:S000002535; FungiDB:YDR128W; VEuPathDB:YDR128W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SEA3
Summary
Predicted to enable signaling adaptor activity. Involved in positive regulation of TORC1 signaling. Located in fungal-type vacuole membrane. Part of Seh1-associated complex. Orthologous to human WDR59 (WD repeat domain 59). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MTC5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (709549..712995)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene palmitoyltransferase SWF1 Neighboring gene pentafunctional protein ARO1p Neighboring gene fimbrin Neighboring gene Fin1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The sea3 mutants exhibited a delay in colony formation in a BIR assay strain after double-strand break (DSB) induction as well as on the DNA-damaging agent bleomycin.
    Title: Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Seh1-associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Seh1-associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Seh1-associated complex IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mtc5p
NP_010413.3
  • Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    709549..712995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180436.3 → NP_010413.3  TPA: Mtc5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010413.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSB4, Q03897
    UniProtKB/TrEMBL
    B5VG26
    Conserved Domains (5) summary
    PLN00181
    Location:143 → 346
    PLN00181; protein SPA1-RELATED; Provisional
    smart00591
    Location:433 → 543
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    sd00039
    Location:29 → 63
    7WD40; WD40 repeat [structural motif]
    pfam17120
    Location:1092 → 1147
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type
    cl29593
    Location:70 → 230
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03897.1

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