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SWF1 palmitoyltransferase SWF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851704, updated on 2-Nov-2024

Summary

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Official Symbol
SWF1
Official Full Name
palmitoyltransferase SWF1
Primary source
SGD:S000002533
Locus tag
YDR126W
See related
AllianceGenome:SGD:S000002533; FungiDB:YDR126W; VEuPathDB:YDR126W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSL10
Summary
Enables palmitoyltransferase activity. Involved in several processes, including cortical actin cytoskeleton organization; protein palmitoylation; and vacuole fusion, non-autophagic. Located in actin cortical patch; actin filament bundle; and nuclear outer membrane-endoplasmic reticulum membrane network. Orthologous to human ZDHHC4 (zinc finger DHHC-type palmitoyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SWF1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (703234..704244)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alpha/beta hydrolase family protein Neighboring gene pentafunctional protein ARO1p Neighboring gene Mtc5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Zinc co-ordination by the DHHC cysteine-rich domain of the palmitoyltransferase Swf1. González Montoro A, et al. Biochem J, 2013 Sep 15. PMID 23790227
  2. Swf1p, a member of the DHHC-CRD family of palmitoyltransferases, regulates the actin cytoskeleton and polarized secretion independently of its DHHC motif. Dighe SA, et al. Mol Biol Cell, 2008 Oct. PMID 18701706, Free PMC Article
  3. A novel motif at the C-terminus of palmitoyltransferases is essential for Swf1 and Pfa3 function in vivo. González Montoro A, et al. Biochem J, 2009 Apr 15. PMID 19138168
  4. Specificity of transmembrane protein palmitoylation in yeast. González Montoro A, et al. PLoS One, 2011 Feb 24. PMID 21383992, Free PMC Article
  5. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys JE, et al. J Cell Biol, 2005 Sep 26. PMID 16186255, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.
    Title: The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.
  2. Data describe a novel 16-amino-acid motif present at the cytosolic C-terminus of palmitoyltransferases, that is required for Swf1 and Pfa3 function in vivo.
    Title: A novel motif at the C-terminus of palmitoyltransferases is essential for Swf1 and Pfa3 function in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament bundle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
palmitoyltransferase SWF1
NP_010411.1
  • Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    703234..704244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180434.1 → NP_010411.1  TPA: palmitoyltransferase SWF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010411.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSB2, Q03889, Q04629
    UniProtKB/TrEMBL
    B3LGF0, B5VG22, C8Z542
    Conserved Domains (1) summary
    COG5273
    Location:22 → 336
    COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04629.2

Gene LinkOut

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