KIN1 serine/threonine protein kinase KIN1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: KIN1
Official Full Name: serine/threonine protein kinase KIN1
Primary source: SGD:S000002529
Locus tag: YDR122W
See related: AllianceGenome:SGD:S000002529; FungiDB:YDR122W; VEuPathDB:YDR122W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein serine/threonine kinase activity. Involved in positive regulation of IRE1-mediated unfolded protein response and positive regulation of exocytosis. Located in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in anencephaly; developmental and epileptic encephalopathy 30; and uterine fibroid. Orthologous to several human genes including NUAK1 (NUAK family kinase 1); NUAK2 (NUAK family kinase 2); and SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of IRE1-mediated unfolded protein response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exocytosis	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed

NP_010407.1

S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated unfolded protein response; regulates HAC1 mRNA translocation, splicing and translation with KIN2 during ER stress; direct phosphorylation of the substrate Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the plasma membrane; activation loop phosphorylation (T302) required for full kinase activity; orthologous to MARK/PAR-1, AMP-activated protein kinase (AMPK) family members

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The following sections contain reference sequences that belong to a specific genome build. Explain