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DPB4 DNA polymerase epsilon noncatalytic subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 851699, updated on 2-Nov-2024

Summary

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Official Symbol
DPB4
Official Full Name
DNA polymerase epsilon noncatalytic subunit
Primary source
SGD:S000002528
Locus tag
YDR121W
See related
AllianceGenome:SGD:S000002528; FungiDB:YDR121W; VEuPathDB:YDR121W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nucleosomal DNA binding activity. Contributes to DNA binding activity; DNA polymerase processivity factor activity; and single-stranded DNA 3'-5' DNA exonuclease activity. Involved in DNA metabolic process; chromatin remodeling; and regulation of DNA double-strand break processing. Part of CHRAC and epsilon DNA polymerase complex. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DPB4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (693585..694175)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cox26p Neighboring gene tRNA (guanine26-N2)-dimethyltransferase Neighboring gene serine/threonine protein kinase KIN1 Neighboring gene Ino2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformational changes associated with template commitment in ATP-dependent chromatin remodeling by ISW2. Gangaraju VK, et al. Mol Cell, 2009 Jul 10. PMID 19595716, Free PMC Article
  2. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. Dang W, et al. J Biol Chem, 2007 Jul 6. PMID 17491017
  3. Synthesis of DNA by DNA polymerase epsilon in vitro. Lee SH, et al. J Biol Chem, 1991 Nov 25. PMID 1682323
  4. Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. Sabouri N, et al. J Biol Chem, 2009 Nov 13. PMID 19776424, Free PMC Article
  5. Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae. Tsubota T, et al. J Biol Chem, 2006 Oct 27. PMID 16916794

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA polymerase processivity factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA polymerase processivity factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosomal DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to single-stranded DNA 3'-5' DNA exonuclease activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in error-prone translesion synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leading strand elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in leading strand elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CHRAC IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CHRAC IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CHRAC IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of epsilon DNA polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of epsilon DNA polymerase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon noncatalytic subunit
NP_010406.3
  • Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    693585..694175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180429.3 → NP_010406.3  TPA: DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010406.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSA7, Q04603
    UniProtKB/TrEMBL
    B3LGF5, B5VG16, C7GIM9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04603.1

Gene LinkOut

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