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APC4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851696, updated on 11-Sep-2024

Summary

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Official Symbol
APC4
Primary source
SGD:S000002525
Locus tag
YDR118W
See related
AllianceGenome:SGD:S000002525; FungiDB:YDR118W; VEuPathDB:YDR118W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and protein ubiquitination. Located in nuclear periphery. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (685882..687840)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MRPL1 Neighboring gene Tma64p Neighboring gene Vba4p Neighboring gene Cox26p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Carroll CW, et al. Nat Cell Biol, 2002 Nov. PMID 12402045
  2. An architectural map of the anaphase-promoting complex. Thornton BR, et al. Genes Dev, 2006 Feb 15. PMID 16481473, Free PMC Article
  3. Modular mass spectrometric tool for analysis of composition and phosphorylation of protein complexes. Blethrow JD, et al. PLoS One, 2007 Apr 4. PMID 17406682, Free PMC Article
  4. Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. Hall MC, et al. J Biol Chem, 2003 May 9. PMID 12609981
  5. Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Zachariae W, et al. Science, 1998 Feb 20. PMID 9469814

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
anaphase promoting complex subunit 4
NP_010403.3
  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    685882..687840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180426.3 → NP_010403.3  TPA: anaphase promoting complex subunit 4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010403.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSA3, Q04601
    UniProtKB/TrEMBL
    B3LGF9
    Conserved Domains (1) summary
    pfam12896
    Location:223 → 411
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04601.1

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