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TMA64 Tma64p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851695, updated on 2-Nov-2024

Summary

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Official Symbol
TMA64
Official Full Name
Tma64p
Primary source
SGD:S000002524
Locus tag
YDR117C
See related
AllianceGenome:SGD:S000002524; FungiDB:YDR117C; VEuPathDB:YDR117C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in rRNA processing. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TMA64 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (683946..685643, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative mitochondrial 54S ribosomal protein Neighboring gene mitochondrial 54S ribosomal protein MRPL1 Neighboring gene anaphase promoting complex subunit 4 Neighboring gene Vba4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Translatome and transcriptome analysis of TMA20 (MCT-1) and TMA64 (eIF2D) knockout yeast strains. Makeeva DS, et al. Data Brief, 2019 Apr. PMID 30815525, Free PMC Article
  2. Differential effects of 40S ribosome recycling factors on reinitiation at regulatory uORFs in GCN4 mRNA are not dictated by their roles in bulk 40S recycling. Jendruchová K, et al. Commun Biol, 2024 Sep 4. PMID 39232119, Free PMC Article
  3. GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor. Dmitriev SE, et al. J Biol Chem, 2010 Aug 27. PMID 20566627, Free PMC Article
  4. 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling. Young DJ, et al. Nat Commun, 2021 May 20. PMID 34016977, Free PMC Article
  5. Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs. Gaikwad S, et al. Elife, 2021 Mar 25. PMID 33764298, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
    Title: 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Tma64p
NP_010402.3
  • hypothetical protein that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    683946..685643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180425.3 → NP_010402.3  TPA: Tma64p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010402.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VSA2, Q04600
    UniProtKB/TrEMBL
    B3LGG0, B5VG12, N1PAD6
    Conserved Domains (3) summary
    cd11608
    Location:474 → 556
    eIF2D_C; C-terminal domain of eIF2D and related proteins
    pfam17832
    Location:2 → 86
    Pre-PUA; Pre-PUA-like domain
    cd21156
    Location:88 → 170
    PUA_eIF2d-like; PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04600.1

Gene LinkOut

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