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PDS1 securin [ Saccharomyces cerevisiae S288C ]

Gene ID: 851691, updated on 2-Nov-2024

Summary

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Official Symbol
PDS1
Official Full Name
securin
Primary source
SGD:S000002520
Locus tag
YDR113C
See related
AllianceGenome:SGD:S000002520; FungiDB:YDR113C; VEuPathDB:YDR113C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme binding activity. Involved in several processes, including negative regulation of exit from mitosis; nuclear division; and recombinational repair. Located in cytoplasm; nucleus; and spindle. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PDS1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (680496..681617, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene replication fork barrier binding protein FOB1 Neighboring gene alanine transaminase ALT2 Neighboring gene uncharacterized protein Neighboring gene putative mitochondrial 54S ribosomal protein Neighboring gene mitochondrial 54S ribosomal protein MRPL1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. Yamamoto A, et al. J Cell Biol, 1996 Apr. PMID 8601616, Free PMC Article
  2. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Cohen-Fix O, et al. Genes Dev, 1996 Dec 15. PMID 8985178
  3. Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast. Salah SM, et al. Chromosoma, 2000. PMID 10855492
  4. A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1. Jensen S, et al. J Cell Biol, 2001 Jan 8. PMID 11149918, Free PMC Article
  5. Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Wang H, et al. Genes Dev, 2001 Jun 1. PMID 11390356, Free PMC Article

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling.
    Title: Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling.
  2. Here, we show that Rts1 is required for the proportional relationship between cell size and growth rate during mitosis. Moreover, nutrients and Rts1 influence the duration and extent of growth in mitosis via Wee1 and Pds1/securin, two conserved regulators of mitotic progression.
    Title: A Conserved PP2A Regulatory Subunit Enforces Proportional Relationships Between Cell Size and Growth Rate.
  3. crystal structures at up to 2.6 A resolution of the yeast Saccharomyces cerevisiae separase-securin complex
    Title: Molecular mechanism for the regulation of yeast separase by securin.
  4. These data indicate that Clb5 and Clb6 promote cohesion which is then protected by Pds1 and that both mechanisms are required during replication stress.
    Title: S-phase cyclin-dependent kinases promote sister chromatid cohesion in budding yeast.
  5. These results define a previously undescribed role for Pds1p in cohesin maintenance, recombination, and meiotic progression.
    Title: Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.
  6. RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
    Title: The Saccharomyces cerevisiae checkpoint genes RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
  7. phosphorylation of Pds1 but not Rad53 correlates with G2 arrest in response to double-strand breaks in the mec1 hypomorphic mutant
    Title: Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant.
  8. protein phosphatase 2A regulates sister chromatid cohesion in Pds1-dependent and -independent manners
    Title: Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.
  9. Chk1-Pds1 checkpoint has roles in preventing tolerance of persistent single-strand breaks in Saccharomyces cerevisiae
    Title: Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in recombinational repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombinational repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
securin
NP_010398.3
  • Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    680496..681617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180421.3 → NP_010398.3  TPA: securin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010398.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS98, P40316
    UniProtKB/TrEMBL
    N1P874
    Conserved Domains (1) summary
    pfam04856
    Location:9 → 356
    Securin; Securin sister-chromatid separation inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40316.1

Gene LinkOut

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