U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAK21 RNA-binding ribosome biosynthesis protein MAK21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851632, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
MAK21
Official Full Name
RNA-binding ribosome biosynthesis protein MAK21
Primary source
SGD:S000002467
Locus tag
YDR060W
See related
AllianceGenome:SGD:S000002467; FungiDB:YDR060W; VEuPathDB:YDR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NOC1
Summary
Enables mRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Part of Noc1p-Noc2p complex. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MAK21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (570649..573726)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene E2 ubiquitin-conjugating protein UBC5 Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The origin of nucleus: rebuild from the prokaryotic ancestors of ribosome export factors. Ohyanagi H, et al. Gene, 2008 Nov 1. PMID 18620034
  2. The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome. Kühn H, et al. PLoS One, 2009 Dec 18. PMID 20019888, Free PMC Article
  3. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
  4. Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. Edskes HK, et al. J Biol Chem, 1998 Oct 30. PMID 9786894
  5. Rrp5 establishes a checkpoint for 60S assembly during 40S maturation. Khoshnevis S, et al. RNA, 2019 Sep. PMID 31217256, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
RNA-binding ribosome biosynthesis protein MAK21
NP_010345.3
  • Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    570649..573726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180368.3 → NP_010345.3  TPA: RNA-binding ribosome biosynthesis protein MAK21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010345.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS46, Q12176
    UniProtKB/TrEMBL
    A6ZY25, C7GVS6, C8Z4X9
    Conserved Domains (1) summary
    COG5593
    Location:173 → 1022
    COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12176.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools