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RAD61 Rad61p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851577, updated on 2-Nov-2024

Summary

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Official Symbol
RAD61
Official Full Name
Rad61p
Primary source
SGD:S000002421
Locus tag
YDR014W
See related
AllianceGenome:SGD:S000002421; FungiDB:YDR014W; VEuPathDB:YDR014W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
WPL1
Summary
Involved in several processes, including chromatin looping; meiotic DNA double-strand break formation; and negative regulation of chromosome organization. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAD61 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (474046..475989)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene DNA replication protein PSF1 Neighboring gene Hed1p Neighboring gene Dad1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Budding yeast Wapl controls sister chromatid cohesion maintenance and chromosome condensation. Lopez-Serra L, et al. Curr Biol, 2013 Jan 7. PMID 23219725
  2. Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis. Challa K, et al. Nucleic Acids Res, 2016 Apr 20. PMID 26825462, Free PMC Article
  3. ROCC, a conserved region in cohesin's Mcd1 subunit, is essential for the proper regulation of the maintenance of cohesion and establishment of condensation. Eng T, et al. Mol Biol Cell, 2014 Aug 15. PMID 24966169, Free PMC Article
  4. A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase. Guacci V, et al. Mol Biol Cell, 2015 Jan 1. PMID 25378582, Free PMC Article
  5. G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in eco1/ctf7 rad61 null cells during hyperthermic stress in Saccharomyces cerevisiae. Buskirk S, et al. G3 (Bethesda), 2022 Jul 29. PMID 35736360, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The unique role of Rad61/Wapl is to promote non-crossover recombination by releasing [Pds5+Rec8]. For this effect, Rad61/Wapl probably acts to maintain homolog bias by preventing channeling into sister interactions.
    Title: Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.
  2. we confirmed that this release indeed accompanies the dissociation of acetylated Smc3 as well as Rec8 from meiotic chromosomes during late prophase-I. This release requires, in addition to PLK, the cohesin regulator, Wapl (Rad61/Wpl1 in yeast), and Dbf4-dependent Cdc7 kinase (DDK)
    Title: Meiosis-specific prophase-like pathway controls cleavage-independent release of cohesin by Wapl phosphorylation.
  3. Rad61/Wpl1 is required for efficient resolution of telomere clustering during meiosis I, indicating a positive effect of Rad61/Wpl1 on the cohesin function required for telomere dynamics.
    Title: Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis.
  4. RAD61 deletion rescues the condensation defect, but importantly, neither the temperature sensitivity nor cohesion defects exhibited by pds5-1 mutant cells.
    Title: Pds5 regulators segregate cohesion and condensation pathways in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rad61p
NP_010297.1
  • Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    474046..475989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180322.1 → NP_010297.1  TPA: Rad61p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VS00, Q99359
    UniProtKB/TrEMBL
    A6ZXX9, B5VFS2, C8Z4T3, N1P615
    Conserved Domains (1) summary
    pfam16997
    Location:254 → 630
    Wap1; Wap1 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99359.1

Gene LinkOut

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