RAD57 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAD57
Primary source: SGD:S000002411
Locus tag: YDR004W
See related: AllianceGenome:SGD:S000002411; FungiDB:YDR004W; VEuPathDB:YDR004W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Involved in heteroduplex formation; meiotic DNA recombinase assembly; and telomere maintenance via recombination. Part of Rhp55-Rhp57 complex. Human ortholog(s) of this gene implicated in breast cancer; familial melanoma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (455201..456583)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.
Title: Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.
The Role of the Rad55-Rad57 Complex in DNA Repair.
Title: The Role of the Rad55-Rad57 Complex in DNA Repair.
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Title: The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
The Rad55-Rad57 heterodimer appears to have a unique function in spontaneous recombination that is not essential for DSB repair.
Title: Suppression of the double-strand-break-repair defect of the Saccharomyces cerevisiae rad57 mutant.
Rad55 and Rad57 have different roles in the recombinational repair of stalled replication forks compared with double-strand break repair.
Title: Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination.
Rad51-independent allelic conversion and break-induced replication occur independently of Rad55, Rad57, and Dmc1 but require Rad52.
Title: Rad51-independent interchromosomal double-strand break repair by gene conversion requires Rad52 but not Rad55, Rad57, or Dmc1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA strand exchange activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA recombinase assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA strand invasion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heteroduplex formation	IDA Inferred from Direct Assay more info	PubMed
involved_in meiosis I cell cycle process	IEA Inferred from Electronic Annotation more info
involved_in meiotic DNA recombinase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Rad51C-XRCC3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative DNA-dependent ATPase RAD57

NP_010287.1

Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

455201..456583

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180312.1 → NP_010287.1 TPA: putative DNA-dependent ATPase RAD57 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010287.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRZ2, P25301

UniProtKB/TrEMBL

B3LGQ4, C8Z4S4, N1PAB4

Conserved Domains (1) summary

cd19491
Location:107 → 445

XRCC3; XRCC3 recombinase