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NOP1 rRNA methyltransferase NOP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851548, updated on 2-Nov-2024

Summary

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Official Symbol
NOP1
Official Full Name
rRNA methyltransferase NOP1
Primary source
SGD:S000002172
Locus tag
YDL014W
See related
AllianceGenome:SGD:S000002172; FungiDB:YDL014W; VEuPathDB:YDL014W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LOT3
Summary
Enables histone H2AQ104 methyltransferase activity and rRNA methyltransferase activity. Involved in box C/D sno(s)RNA 3'-end processing and rRNA methylation. Located in nucleolus. Part of box C/D methylation guide snoRNP complex and small-subunit processome. Orthologous to human FBL (fibrillarin) and FBLL1 (fibrillarin like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NOP1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (427364..428347)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CDC7 Neighboring gene trans-2-enoyl-CoA reductase (NADPH) TSC13 Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. Henríquez R, et al. J Biol Chem, 1990 Feb 5. PMID 2298745
  2. A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. Schimmang T, et al. EMBO J, 1989 Dec 20. PMID 2686980, Free PMC Article
  3. Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly. Tollervey D, et al. Cell, 1993 Feb 12. PMID 8431947
  4. A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. Jansen R, et al. EMBO J, 1993 Jun. PMID 8508778, Free PMC Article
  5. Def1 mediates the degradation of excess nucleolar protein Nop1 in budding yeast. Morshed S, et al. Biochem Biophys Res Commun, 2019 Nov 5. PMID 31506176

See all (190) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein aggregation and the evolution of stress resistance in clinical yeast.
    Title: Protein aggregation and the evolution of stress resistance in clinical yeast.
  2. High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
    Title: High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
  3. Studied and discovered 21 native sites of arginine methylation on five putative Hmt1 substrate proteins (Gar1p, Nop1p, Npl3p, Nsr1p, Rps2p).
    Title: Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AQ104 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AQ104 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in box C/D sno(s)RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in box C/D sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of box C/D methylation guide snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box C/D methylation guide snoRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rRNA methyltransferase NOP1
NP_010270.1
  • Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    427364..428347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180073.1 → NP_010270.1  TPA: rRNA methyltransferase NOP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRX5, P15646, P89890
    UniProtKB/TrEMBL
    A6ZXV4, B3LGS1, C7GW64, C8Z4Q5, G2WCE1, N1P5Y0
    Conserved Domains (1) summary
    PTZ00146
    Location:85 → 320
    PTZ00146; fibrillarin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15646.1

Gene LinkOut

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