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DBP10 putative ATP-dependent RNA helicase DBP10 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851530, updated on 14-Nov-2024

Summary

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Official Symbol
DBP10
Official Full Name
putative ATP-dependent RNA helicase DBP10
Primary source
SGD:S000002189
Locus tag
YDL031W
See related
AllianceGenome:SGD:S000002189; FungiDB:YDL031W; VEuPathDB:YDL031W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA helicase activity. Involved in assembly of large subunit precursor of preribosome; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human DDX54 (DEAD-box helicase 54). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See DBP10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (394217..397204)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Gpr1p Neighboring gene tRNA-5-taurinomethyluridine 2-sulfurtransferase Neighboring gene SF3a splicing factor complex subunit PRP9 Neighboring gene actin-related protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome biogenesis. Burger F, et al. Nucleic Acids Res, 2000 Jun 15. PMID 10871363, Free PMC Article
  2. The sequence of a 36.7 kb segment on the left arm of chromosome IV from Saccharomyces cerevisiae reveals 20 non-overlapping open reading frames (ORFs) including SIT4, FAD1, NAM1, RNA11, SIR2, NAT1, PRP9, ACT2 and MPS1 and 11 new ORFs. Sarén AM, et al. Yeast, 1997 Jan. PMID 9046088
  3. Systematic Analysis of Phosphatidylinositol-5-phosphate-Interacting Proteins Using Yeast Proteome Microarrays. Herianto S, et al. Anal Chem, 2021 Jan 19. PMID 33302626
  4. Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis. Bernstein KA, et al. Mol Cell Biol, 2006 Feb. PMID 16449635, Free PMC Article
  5. A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. Baßler J, et al. J Cell Biol, 2014 Nov 24. PMID 25404745, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis.
    Title: The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis.
  2. The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis.
    Title: The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in assembly of large subunit precursor of preribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of preribosome, large subunit precursor IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
putative ATP-dependent RNA helicase DBP10
NP_010253.2
  • Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    394217..397204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180090.2 → NP_010253.2  TPA: putative ATP-dependent RNA helicase DBP10 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010253.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRW1, Q12389
    UniProtKB/TrEMBL
    C8Z4N7, G2WCC6, N1P7U5
    Conserved Domains (3) summary
    COG0513
    Location:110 → 649
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17959
    Location:137 → 341
    DEADc_DDX54; DEAD-box helicase domain of DEAD box protein 54
    pfam08147
    Location:820 → 880
    DBP10CT; DBP10CT (NUC160) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12389.2

Gene LinkOut

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