SLM3 tRNA-5-taurinomethyluridine 2-sulfurtransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SLM3
Official Full Name: tRNA-5-taurinomethyluridine 2-sulfurtransferase
Primary source: SGD:S000002191
Locus tag: YDL033C
See related: AllianceGenome:SGD:S000002191; FungiDB:YDL033C; VEuPathDB:YDL033C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MTO2; MTU1
Summary: Enables tRNA-5-taurinomethyluridine 2-sulfurtransferase. Involved in mitochondrial tRNA wobble position uridine thiolation. Located in mitochondrion. Used to study MERRF syndrome. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SLM3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (392659..393912, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data strongly indicate that unmodified tRNA caused by the deletion of MTO2 caused the instability of mitochondrial tRNAs and mRNAs and impairment of aminoacylation of tRNAs.
Title: Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae.
The identification and characterization of MTU1 (mitochondrial tRNA-specific 2-thiouridylase 1), a tRNA-modifying enzyme that is responsible for the 2-thiolation of the wobble position in mitochondrial tRNAs. [MTU1]
Title: Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA-5-taurinomethyluridine 2-sulfurtransferase	IEA Inferred from Electronic Annotation more info
enables tRNA-5-taurinomethyluridine 2-sulfurtransferase	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial tRNA wobble position uridine thiolation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA-5-taurinomethyluridine 2-sulfurtransferase

NP_010251.1

EC 2.8.1.14

tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

392659..393912 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180092.1 → NP_010251.1 TPA: tRNA-5-taurinomethyluridine 2-sulfurtransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010251.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRW0, Q12093, Q6IUF4

UniProtKB/TrEMBL

A6ZXT9, B3LGT5, B5VFN3, C7GW49, C8Z4N5, N1P659

Conserved Domains (1) summary

TIGR00420
Location:27 → 407

trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase