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LHP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851509, updated on 11-Sep-2024

Summary

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Official Symbol
LHP1
Primary source
SGD:S000002209
Locus tag
YDL051W
See related
AllianceGenome:SGD:S000002209; FungiDB:YDL051W; VEuPathDB:YDL051W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LAH1; YLA1
Summary
Enables tRNA binding activity. Involved in tRNA processing. Located in nucleolus and nucleoplasm. Orthologous to several human genes including SSB (small RNA binding exonuclease protection factor La). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (363952..364779)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pbp4p Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Neighboring gene Knh1p Neighboring gene Stp4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein expression regulation under oxidative stress. Vogel C, et al. Mol Cell Proteomics, 2011 Dec. PMID 21933953, Free PMC Article
  2. Precise analysis of modification status at various stage of tRNA maturation in Saccharomyces cerevisiae. Ohira T, et al. Nucleic Acids Symp Ser (Oxf), 2009. PMID 19749380
  3. Visual analysis of the yeast 5S rRNA gene transcriptome: regulation and role of La protein. French SL, et al. Mol Cell Biol, 2008 Jul. PMID 18474615, Free PMC Article
  4. Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs. Inada M, et al. Proc Natl Acad Sci U S A, 2004 Jan 13. PMID 14704279, Free PMC Article
  5. Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization. Long KS, et al. RNA, 2001 Nov. PMID 11720288, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the C terminus of Lhp1p, although hypersensitive to proteases in vitro, becomes protease-resistant upon binding pre-tRNAs, U6 RNA, or pre-5S rRNA.
    Title: An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.
  2. The yeast La protein, Lhp1, was associated with 5S genes; its absence had no effect on the amount or size of 5S RNA produced yet resulted in more polymerases per gene on average, consistent with a non-rate-limiting role for Lhp1.
    Title: Visual analysis of the yeast 5S rRNA gene transcriptome: regulation and role of La protein.
  3. Overexpression of the La protein Lhp1p reduces both exonucleolytic pre-tRNA trimming in wild-type cells and the accumulation of defective RNAs in trf4Delta cells.
    Title: Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Lhp1p
NP_010232.1
  • RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    363952..364779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180110.1 → NP_010232.1  TPA: Lhp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010232.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRU5, P33399
    UniProtKB/TrEMBL
    A6ZXS4, B3LGU9, B5VFL6, C7GW88, C8Z4L8, N1P492
    Conserved Domains (1) summary
    COG5193
    Location:1 → 244
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33399.2

Gene LinkOut

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