MBP1 transcription factor MBP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: MBP1
Gene description: transcription factor MBP1
Primary source: FungiDB:YDL056W
Locus tag: YDL056W
See related: SGD:S000002214; AllianceGenome:SGD:S000002214; VEuPathDB:YDL056W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in nucleus. Part of MBF transcription complex. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Deletion of the MBP1 Gene, Involved in the Cell Cycle, Affects Respiration and Pseudohyphal Differentiation in Saccharomyces cerevisiae.
Title: Deletion of the MBP1 Gene, Involved in the Cell Cycle, Affects Respiration and Pseudohyphal Differentiation in Saccharomyces cerevisiae.
TORC1 regulates G1/S transition and cell proliferation via the E2F homologs MBF and SBF in yeast.
Title: TORC1 regulates G1/S transition and cell proliferation via the E2F homologs MBF and SBF in yeast.
Deletion of Mbp1 enhances transcription, suggesting that Mbp1 can also function as transcriptional repressor.
Title: High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae.
the binding site for Xbp1 is present in the target genes of Swi4 and Mbp1 and is conserved phylogenetically
Title: Identification of target genes of a yeast transcriptional repressor.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of translational fidelity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MBF transcription complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MBF transcription complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of SBF transcription complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_010227.1

Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes

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